多巴胺D_2受体调控睡眠-觉醒研究进展  

Progress in sleep-wake regulation of dopamine D_2 receptor

作　　者：许奇[1] 曲卫敏[2] 黄志力[1,3] 

机构地区：[1]复旦大学医学神经生物学国家重点实验室,上海200032 [2]复旦大学上海医学院药理学系,上海200032 [3]上海医学院药理学系,上海200032

出　　处：《中国临床药理学与治疗学》2010年第4期361-366,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(30625021;30821002;30970955);国家"重大新药创制"科技重大专项(2009ZX09303-006);上海市科委基金(09PJ1401800;09JC1402500;10XD1400400);上海市重点学科建设项目(B119)

摘　　要：脑内多巴胺(dopamine,DA)参与觉醒相关的运动、认知和奖赏等行为调控。DA能神经元主要位于黑质致密部和腹侧被盖区。DA受体(receptor,R)包括:D_1R、D_2 R(D_(2S)和D_(2L))、D_3 R、D_4R和D_5R五种亚型。中枢神经内D_1R和D_2R数目占绝对优势,D_2R对内源性DA的亲和力显著高于D_1R。近年来,药理学和基因剔除动物等研究发现:D_2R是维持觉醒的重要受体,本文综述其研究进展。Dopamine（DA） modulates diverse wake-related behaviors including movement,reward, and cognition.Dopaminergic neurons are located in the substantia nigra pars compacta and ventral tegmental area.There are five distinct DA receptors（R）：D1R,D2R（D2SR and D2LR）, D3R,D4R and D5R in the central nervous system, in which D1R and D2R are majorly expressed. The affinity of D2R for endogenous DA is significantly higher than that of D1R.Recently,studies by pharmacological and gene knock-out animals revealed that dopamine D2R is essential inmaintaining wakefulness.Here,we review the progress on roles of D2R in sleep-wake regulation.

关 键 词：多巴胺 D2受体 睡眠 觉醒 基因剔除小鼠 

分 类 号：R96[医药卫生—药理学]