黄芪对放射性肺损伤干预作用及对肿瘤坏死因子-α和内皮素表达影响的研究  

Intervention of Astragalus membranaceus on radioactive lung injuries and influence on TNF-α and ET expression

作　　者：奚蕾[1] 夏德洪[1] 沈伟生[1] 周剑波[1] 舒中琴[1] 于波[1] 侯昕珩[1] 王珂[1] 

机构地区：[1]东南大学医学院附属江阴医院,江阴214400

出　　处：《中华放射医学与防护杂志》2010年第3期327-329,共3页Chinese Journal of Radiological Medicine and Protection

基　　金：江苏省中医药局中医药科研项目（HZ07092）

摘　　要：目的 观察黄芪对中晚期胸部肿瘤放射治疗的肺保护作用及对肿瘤坏死因子-α（TNF-α）和内皮素（ET）表达水平的影响.方法 将中晚期胸部肿瘤放射治疗患者79例随机分为治疗组（41例）和对照组（38例）.治疗组在放射治疗开始起服用黄芪10 ml,2次/d,连续6个月,对照组为单纯放射治疗.放射治疗前后测定血浆TNF-α和ET,放射治疗开始15 d起观察临床症状、影像学改变和肺弥散功能.结果 在放射治疗后测定血浆TNF-α和ET,治疗组分别为（2.48±0.75）as/ml和（69.32±23.03）pg/ml;对照组分别为（5.12±1.01）ng/ml和（97.87±37.83）pg/ml;对照组较治疗组明显升高（χ^2=7.49、6.57,P〈0.001）.放射治疗开始后5个月和10个月治疗组CO弥散量下降情况较对照组差异有统计学意义（χ^2=3.98、3.78,P〈0.05）.结论 黄芪能抑制放射治疗后血浆TNF-α和ET的过度表达,降低放射治疗后弥散功能的恶化,用于放射性肺损伤的干预.Objective To observe the lung protection of Astragalus membranaceus against radiotherapy to intermediate-stage and terminal thoracic neoplasm, and its influence on TNF-α and ET expression.Methods The patients with intermediate-stage and terminal thoracic neoplasm under radiotherapy were divided into a treatment group and a control group.Patients in the treatment group took 10 ml of Asragalus membranaceus twice a day.for consecutive 6 months from the beginning of radio therapy.TNF-α and ET in the plasma were measured before and after the radiotherapy.The clinical symptom,iconographic changes and lung diffusion were observed from the 15th day of radiotherapy.Results The TNF-α and ET in plasma afterthe radiotherapy were（2.48±0.75）as/ml and（69.32±23.03）pg/ml for the treatment group,and（5.12±1.01）ns/ml and（97.87±37.83）pg/ml for the control group with the statistial difference（x^2=7.49,6.57,P〈0.001）.The decrease of CO diffusion 5 and 10 months after the radiotherapy in the treatment group was statistically different compared with that in the control group（x^2=3.98,3.78,P〈0.05）.There was a statistical difference of the incidence of acute radiation pneumonitis and pulmonary fibrosis between these two groups（P〈0.05）.Conclusions Astragalus membranaceus could inhibit the excess expression of TNF-α and ET in plasma and reduce the deterioration of diffusion after radiotherapy,so that it can be used for intervention of lung injuries from radiotherapy.

关 键 词：放射治疗 黄芪 肺损伤 辐射防护 肿瘤坏死因子-Α 内皮素 

分 类 号：R285.5[医药卫生—中药学]