微囊包膜新生猪胰岛移植逆转糖尿病大鼠甲状腺形态学改变  

Microencapsulated neonatal porcine islet transplantation reverses the morphological changes of thyroids in diabetic rats

作　　者：李佐强[1,2] 刘纯[1,2] 何军[1,2] 舒昌达 

机构地区：[1]重庆医科大学附属第一医院内科 [2]上海市第二人民医院

出　　处：《中华器官移植杂志》1999年第1期20-21,共2页Chinese Journal of Organ Transplantation

摘　　要：目的探讨糖尿病大鼠胰岛移植后的甲状腺形态学的变化。方法给用链脲霉素所致的糖尿病大鼠腹腔内移植微囊包膜的新生猪胰岛８００个。术后３个月将动物处死，取甲状腺切片观察。结果动物处死前对照组及移植组的血糖水平分别为（４．８７±０．４７）ｍｍｏｌ／Ｌ和（６．４４±１．８２）ｍｍｏｌ／Ｌ，糖尿病组为（１６．１２±１．４７）ｍｍｏｌ／Ｌ，移植组与对照组比较，差异不显著（Ｐ＞０．０５），糖尿病组与对照组比较，差异显著（Ｐ＜０．００１）；甲状腺滤泡腔内胶质的面积，移植组、糖尿病组分别与对照组比较，差异不显著，但甲状腺滤泡上皮细胞的高度，糖尿病组与对照组相比，差异显著（Ｐ＜０．００１），而移植组与对照组相比，差异不显著（Ｐ＞０．０５）。结论胰岛移植后若受体的血糖控制良好，其甲状腺滤泡上皮细胞的形态改变可以逆转，这可能是纠正糖尿病时甲状腺分泌功能低下的重要因素之一。Objective To investigate the morphological changes of the thyroids in diabetic rats undergoing the transplantation of microencapsulated neonatal porcine islets.Methods 800 microencapsulated neonatal porcine islets were transplanted intraperitoneally into streptozotocin induced diabetic rats. Three months after the islet transplantation, all animals were killed, and the thyroid sections were observed. Results The levels of plasma glucose(PG) were ( 4.87 ± 0.47 )mmol/L in control group(CG) and ( 6.44 ± 1.82 )mmol/L in transplantation group (TG), and ( 16.12 ± 1.47 )mmol/L in diabetes group (DG) before decapitation of the animals. No significant difference was found in PG between TG and CG( P > 0.05 ), but the difference in PG between DG and CG was significant ( P < 0.001 ). The colloid areas in the follicular lumens of the thyroids in TG and DG showed no significant difference as compared with those in CG, but the cell heights of the follicular epithelium of the thyroids (CHFET) in DG had a significant difference as compared with those in CG ( P < 0.001 ), whereas no significant difference was observed in CHFET between TG and CG( P > 0.05 ). Conclusion The morphological change of the epithelial cells of the thyroid follicle in the recipients may be reversed if its PG was effectively controlled after islet transplantation, which may contribute to reversing the thyroid hyposecretion function in diabetes mellitus.

关 键 词：胰岛移植 异体移植 糖尿病 甲状腺形态 实验研究 

分 类 号：R587.105[医药卫生—内分泌] R657.5[医药卫生—内科学]