14例胰岛素依赖型糖尿病患者胚胎胰腺组织移植的远期临床分析  

Long-term results of fetal pancreatic tissue transplantation in patients with insulin dependent diabetes mellitus: an analysis of 14 cases

作　　者：孟庆敏[1] 龚家镇[1] 文武[1] 周鸣淑[1] 刘惠玲[1] 

机构地区：[1]首都医科大学附属北京同仁医院

出　　处：《中华器官移植杂志》1999年第1期25-26,共2页Chinese Journal of Organ Transplantation

摘　　要：目的观察胰腺组织移植的远期效果。方法将胚胎胰腺制成１ｍｍ×１ｍｍ×１ｍｍ大小的组织块，经培养后移植至胰岛素依赖型糖尿病患者的大网膜及小网膜腔内。结果术后１４例患者的胰岛素用量均较术前减少，低血糖出现的时间为术后７～３７天。术后５年、６年、７年和８年的胰岛素用量分别为（４５．８６±１６．８３）Ｕ／ｄ、（４６．９１±１８．３４）Ｕ／ｄ、（４８．６０±１７．０２）Ｕ／ｄ和（５２．６７±１４．１４）Ｕ／ｄ，与术前比较，差异均有显著意义（Ｐ＜０．０１）。结论胚胎胰腺组织移植具有一定的远期效果，可作为胰岛素依赖型糖尿病的一种有效的治疗方法；术后效果与移植的胰岛数量。Objective To observe the long term effects of human fetal pancreatic tissue transplantation. Methods Cultured human fetal pancreatic fragments(1mm×1mm×1mm) were implanted into the greater omentum and omental bursa of 14 patients with insulin dependent diabetes mellitus(IDDM).Results Postoperative reduction of exogenous insulin requirements was noted in all 14 cases. Hypoglycemia appeared in the 7th～37th postoperative days. In the 5th, 6th, 7th and 8th postoperative years, the required mean regular insulin doses were ( 45.86 ± 16.83 )U/d, ( 46.91 ± 18.34 )U/d, ( 48.60 ± 17.02 )U/d and ( 52.67 ± 14.14 )U/d respectively, which were significantly different from the preoperative ones( P< 0.01 ).Conclusion Fetal pancreatic tissue transplantation has certain long term effects and could be used as an effective way for treating IDDM. Postoperative efficacy is related to the quantity and quality of islet cells and islet rejection.

关 键 词：糖尿病 NIDDM 胰腺组织移植 胚胎 

分 类 号：R587.105[医药卫生—内分泌] R657.5[医药卫生—内科学]