单扫描示波极谱法测定药物中头孢唑啉钠含量  

Determination of Cefazolin Sodium by Linear-sweeping Oscillopolarography

作　　者：李艳霞[1] 谢东坡[1] 

机构地区：[1]周口师范学院化学系,河南周口466000

出　　处：《化学世界》2010年第6期324-326,共3页Chemical World

基　　金：河南省教育厅自然科学基金资助项目(2008B150024)

摘　　要：在稀H2SO4介质中，头孢唑啉钠在滴汞电极上于-0．70V（vs．SCE）处产生一灵敏的极谱还原峰，头孢唑啉钠的浓度在0．8-600μg／mL范围内与其所产生的峰电流呈线性关系，建立了用单扫描示波极谱法测定药物中头孢唑林钠含量的新方法，此方法检出限为0．41μg／mL。用于实际药品制定，结果与药典法一致。In a supporting electrolyte containing dilute H2SO4, a reductive peak of cefazolin sodium was observed at --0. 70 V （vs. SCE）. A liner relationship was found between the intensity of the cefazolin sodium peak and the concentration of cefazolin sodium in the range of 0.8-600 μg/mL, and the detection limb was 0. 41μ g/mL. A new method for the determination of cefazolin sodium by linear-sweeping oscillopolarography was established. The results agree very well with those obtained by the conventional pharmacopoeial method.

关 键 词：单扫描示波极谱法 头孢唑啉钠 药物 

分 类 号：O657.14[理学—分析化学] TQ460.7[理学—化学]