亚低温治疗对重型颅脑创伤患者脑脊液中细胞因子水平的影响  

Effect of moderate hypothermia on inflammatory cytokines levels in cerebrospinal fluid after severe traumatic brain injury

作　　者：石滴坚[1] 程泽沛[1] 冯怡墨[1] 曾龙威[1] 

机构地区：[1]重庆市第三人民医院神经外科,重庆400014

出　　处：《重庆医科大学学报》2010年第5期759-761,共3页Journal of Chongqing Medical University

摘　　要：目的:探讨亚低温治疗对重型颅脑损伤患者(Severe traumatic brain injury,STBI)脑脊液中肿瘤坏死因子-α(Tumornecr osis factor alpha,TNF-α)、白介素6(Interleukin-6,IL-6)及白介素8(Interleukin-8,IL-8)的影响及临床意义。方法:选择符合条件的STBI共40例者(格拉斯哥评分(Glasgow Coma Scale score,GCS)≤8分,伤后6h内入院)随机分为亚低温组和常温对照组各20例,采用放射免疫法检测亚低温治疗前后不同时段脑脊液(Cerebrospinal fluid,CSF)中IL-6、IL-8及TNF-α水平的变化。结果:亚低温治疗组STBI血清IL-6、IL-8及TNF-α浓度较常规治疗组明显降低(P<0.05)。结论:亚低温治疗STBI通过细胞因子的水平,减少了患者多器官功能障碍综合征(Multiple organfailure,MODS)的发生,降低了死亡率,改善了临床预后。Objective：To investigate the effect of moderatehy pothermia on tumor necrosis factor alpha（TNF-α）,interleukin-6（IL-6） and intedeukin-8（IL-8）in cerebrospinal fluid（CSF）of patients with severe traumatic brain injury（STBI）and its clinical significance.Methods：Forty patients with severe traumatic brain injury were randomly divided into hypothermic group and control group.Inclusion criteria included Glasgow Coma Scale（GCS）score ≤8 and time of after injury to on admission must be within 6 hours.TNF-α,IL-6,IL-8concentrations of CSF were tested before and after hypothermic therapy by radioimmunoassay.Results：Levels of serum TNF-α,IL-6 and IL-8 were decreased more significantly in the moderate hypothermia group than the control group（P〈0.05）.Conclusion：Moderate hypothermia can decrease cytokines levels in patients with severe brain injury and hence reduce incidence of multiple organ dysfunction syndrome,the mortality and improve the clinical prognosis of STBI.

关 键 词：脑损伤 低温 细胞因子 

分 类 号：R651[医药卫生—外科学]