Graves甲亢患者外周血白细胞糖皮质激素受体改变的意义  

Determination and clinical significance of the binding capacity of glucocorticoid receptor on peripher alleukocytes from patients with Graves disease

作　　者：周桂莲[1] 张弛[1] 李华珠[1] 

机构地区：[1]湖南省人民医院内分泌科,长沙410005

出　　处：《重庆医科大学学报》2010年第5期773-775,共3页Journal of Chongqing Medical University

摘　　要：目的:观察Graves甲亢患者外周血白细胞糖皮质激素受体(Glucocorticoid receptor,GR)的改变,探讨其在发病中的作用。方法:61例首诊Graves甲亢,采用放射配体结合法测定白细胞GR水平,并以同期健康体检者20例作为对照,分析GR水平变化的意义。结果:甲亢组GR比正常对照组明显降低(t=7.389,P=0.0001)。61例甲亢患者随严重程度增加,GR水平逐渐下降(F=7.389,P=0.0001)。GR水平和甲状腺激素FT3、FT4及TSH均呈负相关,相关系数分别为0.741(t=5.643,P=0.013),0.689(t=5.119,P=0.025)和0.755(t=6.391,P=0.009)。61例甲亢患者并发甲亢性突眼者GR水平下降(t=4.274,P=0.0001),而并发甲亢性心脏病(t=0.273,P=0.786)和甲亢性周期麻痹者(t=0.961,P=0.336)GR水平未见有统计学意义的下降。结论:Graves甲亢患者外周血白细胞GR水平下降,并且跟病情严重程度、是否并发甲亢性突眼者有关。Objective：To observe the change and clinical significance of glucocorticoid receptor on peripher alleukocytes frompatients with Graves disease.Methods：By radioligand binding assay,GR contents of peripher alleukocytes were determinated in 61 patients with Graves disease,20 healthy volunteers as controls.Results：The GR contents in Graves disease group were significantly lower than that of the normal control group（t = 7.389,P = 0.000 1）.In 61 patients with graves disease,GR contents gradually decreased（F = 7.389,P = 0.000 1）with increased Graves disease severity.GR contents were negatively correlated with FT3,FT4 and TSH,correlation coefficients were 0.741（t = 5.643,P = 0.013）,0.689（t = 5.119,P=0.025）and 0.755（t =6.391,P=0.009）,respectively.GR contents were decreased（t = 4.274,P= 0.000）while patients complicated bythyrotoxic exophthalmos,but GR contents were not statisticallysignificantlydeclined while patients complicated by hyperthyroid heart disease（t = 0.273,P = 0.786） or thyrotoxic periodic paralysis were（t =0.961,P = 0.336）.Conclusion：The binding capacity of GR on peripheral leukocytes in the Graves disease patients is lower than normal.This change may play roles in the pathogenic process of Graves disease and probably relate to the disease severity,thyrotoxic exophthalmos complicated.

关 键 词：GRAVES病 糖皮质激素受体 放射配体结合法 

分 类 号：R582.1[医药卫生—内分泌]