肾移植患者外周血循环内皮细胞检测及其意义  

Detection and Significance of Endothelial Cell Function in Peripheral Blood of Renal Allograft Recipients

作　　者：侯铸[1] 姜永光[1] 管德林[2] 罗勇[1] 夏成青[3] 

机构地区：[1]北京安贞医院泌尿外科,北京100029 [2]北京朝阳医院泌尿外科 [3]北京朝阳医院病理科

出　　处：《临床泌尿外科杂志》2010年第5期339-340,共2页Journal of Clinical Urology

摘　　要：目的:通过对肾移植患者外周血循环内皮细胞数量检测,探讨肾移植患者内皮细胞损伤情况及意义。方法:在术前、术后第3、7、10、14天及肾功能异常当天对患者外周血循环毛细血管内皮细胞(capillary endothelialcell,CEC)及其碎片的数量,用巨细胞病毒(cytomegalo virus,CMV)、PP65进行检测,在肾功能异常当天作肾穿刺活检以明确诊断。结果:肾移植患者术前,术后肾功能稳定期,急性排斥反应、急性肾小管坏死(acutetubular necrosis,ATN)、环孢素中毒、CMV感染时CEC数量均显著高于健康对照组,差异有统计学意义。结论:肾移植患者术后肾功能稳定期及ATN、CMV感染及急性排斥反应时均有不同程度的内皮细胞损伤,内皮细胞的损伤在移植肾动脉硬化的发生发展中起重要作用。Objective：To detect and assess the impairment of the endothelial function of peripheral blood of re nal allograft recipients. Methods： To detect CEC at pre-operation and post operation 3,7,10, 14 d. At the same time, the number of fragments with CMV （cytomegalo virus, CMV ）, PP65 were detected in the renal function of renal biopsy for the day to confirm the diagnosis. Results： Renal transplant patients before surgery, stable renal function, acute rejection, acute tubular necrosis （acute tubular necrosis, ATN）, cyclosporine toxicity, CMV infection, the number of CEC were significantly higher than the control group, the difference statistically significant. Conclusions： The patients with stable renal rejection and ATN, infection of CMV, acute renal tubular necro- sis have a certain endothelial injury. CEC play an important pole in renal artery sclerosis.

关 键 词：肾移植 外周血 内皮细胞 

分 类 号：R699.2[医药卫生—泌尿科学]