MCM-41/PAA的制备及释药性能  

PREPARATION AND DRUG RELEASE PROPERTY OF MCM-41/PAA

作　　者：曹渊[1] 王晓[1] 吕丽丹[1] 位玉仃[1] 何雪梅[1] 吴慧[1] 

机构地区：[1]重庆大学化学化工学院,重庆400030

出　　处：《硅酸盐学报》2010年第6期1080-1085,共6页Journal of The Chinese Ceramic Society

基　　金：中国博士后科学基金(20080440696);国家大学生创新基金(081061119081061119);重庆大学研究生创新基金(201005A-1A0010332);"211工程"三期建设(S–09103)资助项目

摘　　要：采用微波辅助法合成介孔分子筛(mesoporous molecular sieve)MCM-41,将其与丙烯酸(acrylic acid,AA)经原位聚合,制备具有pH敏感性的新型复合材料MCM-41/聚丙烯酸(polyacrylic acid,PAA)。通过X射线衍射、Fourier红外分析、热重分析、N2吸附/脱附等表征材料的结构和性能,证明合成了一种新型高分子复合材料。以抗压利尿药物氢氯噻嗪为模型药物,通过液体紫外法研究复合材料的载药性能及其在人工胃液(pH=1.2)和人工肠液(pH=6.8)条件下的释药性能。结果显示:MCM-41/PAA的载药量达51.75%,在人工胃液和人工肠液的体外模拟释药过程中显示出良好的pH控释的敏感性。这种材料可以用于肠道靶向控释领域。Mesoporous molecular sieve （MCM-41） was synthesized by the microwave method,and then MCM-41/acrylic acid （AA） which is sensitive to pH value was synthesized by the polymerization of the MCM-41 with the AA in situ. The materials were charac-terized by the X-ray diffraction,Fourier transform infrared spectroscopy,thermogravimetry analysis,and nitrogen absorption-desorption,etc. It is found that a new polymer composite is synthesized. Selecting hydrochlorothiazide as a model drug,the properties of drug loading and release behaviors under different pH values were examined by the ultraviolet spectrophotometry. The results show that MCM-41/polyacrylic acid （PAA） has a high hydrochlorothiazide storage capacity of 51.75%. In vitro test result shows high pH sensitivity in simulated gastric fluid （pH = 1.2） and simulated intestinal fluid （pH = 6.8）. The MCM-41/PAA composite has a potential application in area of intestinal targeting drug release.

关 键 词：介孔分子筛 PH敏感 药物控释 聚丙烯酸 

分 类 号：O614[理学—无机化学]