恶性肿瘤化学治疗致药物性胃炎80例的临床分析  

CANCER CHEMOTHERAPY DRUG-INDUCED GASTRITIS CAUSED BY THE CLINICAL ANALYSIS OF 80 CASES

作　　者：韦嵩[1] 

机构地区：[1]广西河池市人民医院肿瘤科,河池547000

出　　处：《现代预防医学》2010年第12期2392-2393,共2页Modern Preventive Medicine

摘　　要：[目的]分析恶性肿瘤化学治疗致药物性胃炎临床症状及治疗。[方法]选择2001年6月-2008年12月于我院病理学或细胞学检查为Ⅲ-Ⅳ期恶性实体肿瘤患者80例,随机分为对照组（40例）与观察组（40例）,于第2疗程化疗同时,观察组采用泮托拉唑/奥美拉唑40mg/d,地西泮5mg,2次/d,格拉司琼3mg/d的方法;对照组采用雷尼替丁0.2-0.4/d,地西泮5mg,2次/d,格拉司琼3mg/d。对两组患者进行观察、疗效比较并分析不良反应及依从性等。[结果]80例患者中46例经对照期化疗出现胃黏膜损伤,41例出现药物性胃炎表现。观察组中症状完全控制者占75.0%,对照组中症状完全控制者占57.5%,两组比较差异有统计学意义（P﹤0.05）。观察组上消化道症状发生率仅有25%,而对照组有45.0%,两组比较差异有统计学意义（P﹤0.05）;对照组与观察组出现不良反应比率差异无统计学意义（P﹥0.05）;观察组每例平均完成5.4个化疗疗程;对照组每例平均完成4.5个疗程。[结论]化疗中药物性胃炎发生率高,应根据具体情况具体分析,选择最佳用药方案。[Objective] To analyze the chemical treatment of malignant tumors caused by drug-induced gastritis symptoms and treatment.[Methods] from June 2001 to December 200880 patients with malignant solid tumors diagnosed by pathology or cytology as Ⅲ-Ⅳ were randomly divided into control group（40 cases） and the observation group（40 cases）.In the 2 cycles of chemotherapy at the same time,the observation group treated with pantoprazole /omeprazole 40mg /day,diazepam 5mg,2 times /day and granisetron 3 mg /day;The control group was treated with ranitidine 0.2-0.4 /day,diazepam 5 mg,2 times /day and granisetron 3mg /day.We observed the two groups,compared their efficacy and analyzed the adverse reactions and compliance.[Results] Among 80 patients,46 patients with gastric mucosal injury occurred in control of chemotherapy,41 patients had the performance of drug-induced gastritis.The full control symptoms of observation group accounted for 75.0%,and it in control group accounted for 57.5%.There were significant difference between the two groups（P﹤0.05）.The rate of upper gastrointestinal symptoms in the observation group was 25%,while was 45.0% in the control group,and there was significant difference in the two groups（P﹤0.05）;The adverse reaction rate in the two groups has no significant difference（P﹥ 0.05）;The observation group completed an average of 5.4 per patient chemotherapy treatment;and the control group completed an average of 4.5 per patient treatment.[Conclusion] The incidence of drug-induced gastritis showed high during chemotherapy,and we should choose the best medications according to the on the specific circumstances.

关 键 词：肿瘤 化学治疗 药物性胃炎 

分 类 号：R979.1[医药卫生—药品]