CA125与腺苷脱氨酶在结核性胸膜炎患者中的临床意义  

The clinical significance of CA125 and ADA in patients with tubercalous plearitis

作　　者：张春智[1] 张西雁[1] 李霞[1] 蒋幼凡[2] 

机构地区：[1]重庆市肺科医院,400020 [2]重庆医科大学附属第二医院,400010

出　　处：《重庆医学》2010年第12期1550-1551,共2页Chongqing medicine

摘　　要：目的探讨血清及胸水CA125、腺苷脱氨酶(ADA)测定在结核性胸膜炎患者中的临床意义。方法应用化学免疫放光法测定30例非结核性胸水患者及48例结核性胸膜炎患者治疗前、后血清及胸水CA125、ADA,并计算特异度、敏感度、阳性预测值、阴性预测值、准确度。结果结核性胸膜炎患者CA125、ADA阳性率较高,血清中联合检测较单项检测除特异度略有提高,敏感度、准确度无明显提高;胸水中联合检测较单项检测敏感度无提高,特异度、准确度均有明显提高。结论血清CA125、ADA联合检测对结核性胸膜炎辅助诊断价值不大;胸水中联合检测对结核性胸膜炎辅助诊断价值突出。Objective To explore the clinical significance of determination of CA125 and ADA in blood serum and pleural fluid in patients with tuberculous pleuritis. Methods Chemo-immumo fluorescence method was used to determine CA125 and ADA in blood serum and pleural fluid of 30 patients without tuberculous pleuritis and 48 ones who suffered from tuberculous pleuritis.Then calculated their specificity,sensitivity,positive predictive value,negative predictive value and accuracy rating.Results The positive rating of CA125 and ADA in patients with tuberculous pleuritis was higher.Compared single item with symphysial detection,the latter in blood serum there was a little adscendent in specificity,but not obviously adscendent in sensitivity and accuracy rating.In pleural fluid there were obviously raise in specificity and accuracy rating,while not descent in specificity.Conclusion Symphysial detection of CA125 and ADA in blood serum is not helpful to auxiliary diagnosis in tuberculous pleurisy,but the symphysial detection in pleural fluid is extremely utility.

关 键 词：CA125 ADA 结核性胸膜炎 临床意义 

分 类 号：R521.704[医药卫生—内科学]