冠心病患者血浆肾上腺髓质素前体N端20肽与缩血管活性物质关系的探讨  

Relationship of roadrenomedullin N terminal 20 peptide and the other vasoconstrictive substance in patients with coronary artery disease

作　　者：辛苏宁[1] 马健[1] 王惠敏[1] 庞继恩[1] 王翼[1] 唐朝枢[2] 

机构地区：[1]解放军第401医院,青岛266071 [2]北京大学医学部,100080

出　　处：《重庆医学》2010年第12期1564-1565,共2页Chongqing medicine

摘　　要：目的观察冠心病患者血浆肾上腺髓质素前体N端20肽(PAMP)与缩血管活性物质之间的关系并探讨其临床意义。方法经冠状动脉造影确诊的冠心病患者66例被分为稳定性心绞痛组(SA)、不稳定性心绞痛组(UA)与急性心肌梗死组(AMI),对照组为经冠状动脉造影证实无冠心病的患者,所有研究对象用放射免疫分析法测定血浆PAMP、血管紧张素Ⅱ(AngⅡ)与内皮素(ET)含量。结果对照组、SA组、UA组与AMI组PAMP血浆含量(ng/L)依次为5.55±0.97、9.25±2.95、13.07±1.29、15.52±4.60,冠心病患者PAMP血浆含量明显高于对照组(P<0.01),AngⅡ与ET在UA组与AMI组明显高于对照组(P<0.01)。UA组与AMI组血浆PAMP水平与AngⅡ、ET呈显著正相关(P<0.01)。结论冠心病患者血浆PAMP浓度增高,并且和缩血管物质AngⅡ、ET明显相关,可能与拮抗AngⅡ、ET的缩血管作用有关。Objective To study the relationship of proadrenomedullin N terminal 20 peptide（ PAMP ） and the other vasoconstrictive substance in patients with coronary artery disease （CAD） and its clinical significance.Methods The 66 patients with CAD were divided into three groups： 21 patients were suffering from stable angina （SA）, 29 patients unstable angina （UA） and 16 patients acute myocardial infarction （AMI）.23 patients excluding CAD were studied as control,Venous blood samples were collected and the plasma levels of PAMP,angiotensinⅡ（AngⅡ）,endothilin（ET） were measured by radioimmunoassy. Results The plasma levels of PAMP ng/L was 5.55±0.97 in control group, and 9.25±2.95、13.07±1.29、15.52±4.60 in SA group,UA group and AMI group respectively, which were significantly higher in CAD patients than that in control group （ P0.01 ）.The levels of AngⅡ and ET in UA group and AMI group were higher than that in control group （ P0.01 ）.There was a significantly positive correlation between plasma levels of PAMP and AngⅡ,ET（P0.01） in UA group and AMI group.Conclusion The PAMP levels of plasma in CHD patients are elevated and significantly correlation between PAMP and AngⅡ,ET in patients with acute artery disease syndrome.It suggest that the elevation plasma level of PAMP may resist role of vasoconstrictive substance.

关 键 词：冠心病 肾上腺髓质素前体N端20肽 放射免疫分析 

分 类 号：R541.4[医药卫生—心血管疾病]