正交设计优选黄桂灌肠剂的处方  

Orthogonal design of formula optimization for Huanggui enema

作　　者：邓丽琴[1] 张岩[1] 

机构地区：[1]无锡市妇幼保健院,江苏无锡214002

出　　处：《药学实践杂志》2010年第3期203-205,共3页Journal of Pharmaceutical Practice

摘　　要：目的优选黄桂灌肠剂处方。方法采用正交试验设计法进行处方中各成分的用量筛选,以小鼠廓清指数提高百分率和体外抑菌作用为考察指标,确定黄桂灌肠剂的最佳处方并进行验证试验。结果优选的黄桂灌肠剂的最佳处方为1 000 ml中含黄连60 g、黄柏180 g、桂枝120 g,大黄48 g,考察指标中,小鼠廓清指数提高百分率>20%,抑菌圈直径>35mm,结果达到要求。结论优选的黄桂灌肠剂处方合理,为临床应用提供了实验依据。Objective To choose the best formula for Huanggui enema.Methods The orthogonal test was used to optimize formula,and the clearance index in mice and antibacterial action in vitro were observation index.The best formula was designed according to the result of this study.Results The formula is： Rhizoma Coptids 60 g,Cortex phellodendn 180 g,Ramulus Cinnamoni 120 g,Radixet Rhizoma Rhei 48 g per 1 000 ml.The clearance index in mice is greater 20%,diameter of inhibition zone is greater 35 mm.Conclusion The optimized formula is reasonable and provided an experimental basis for clinical application.

关 键 词：黄桂灌肠剂 正交设计 处方优选 动物实验 抑菌试验 

分 类 号：R943[医药卫生—药剂学]