葡萄糖氯化钠钾注射液与注射用盐酸头孢吡肟配伍的稳定性  

Compatible stability of glucose and sodium potassium chloride injection mixing with cefepime Hydrochloride for injection

作　　者：魏京海[1] 毕开顺[2] 马爱玲[2] 陈晓辉[2] 

机构地区：[1]首都医科大学附属北京儿童医院药剂科,北京100045 [2]沈阳药科大学药物分析教研室,辽宁沈阳110016

出　　处：《药学实践杂志》2010年第3期213-214,共2页Journal of Pharmaceutical Practice

摘　　要：目的研究在室温下葡萄糖氯化钠钾注射液(简称GNK)与注射用盐酸头孢吡肟配伍后的稳定性。方法采用RP-HPLC法测定配伍后注射用盐酸头孢吡肟的含量变化,同时考察配伍溶液的外观、pH值和不溶性微粒的变化。结果在室温下配伍溶液8 h内均无气体或沉淀产生,pH值、不溶性微粒和含量均无明显变化。结论 GNK与注射用盐酸头孢吡肟配伍后8 h稳定,在8 h内可安全应用于临床。Objective To study the stability of glucose and sodium potassium chloride injection（GNK） mixing with cefepime hydrochloride in room temperature.Methods RP-HPLC was applied to determine the content change of cefepime hydrochloride in different time.The pH,quantity of non-soluble particulate and appearance of mixtures were also observed.Results In room temperature the mixtures produced neither gas nor sediment.The pH,quantity of non-soluble particulate and content did not change within 8 hours.Conclusion The mixtures of GNK mixing with cefepime hydrochloride are stable in 8 hours.

关 键 词：配伍稳定性 葡萄糖氯化钠钾注射液 盐酸头孢吡肟 

分 类 号：R978.11[医药卫生—药品]