中等取代度的羟丙基-β-环糊精对地塞米松的包埋特性研究  

The complex forming ability of medium substituted degree hydroxypropyl-β-cyclodextrins on dexamethasone

作　　者：张玥[1] 韩静[1] 张多婷[1] 杨静[1] 孙铭[1] 项文娟[1] 

机构地区：[1]沈阳药科大学制药工程学院,辽宁沈阳110016

出　　处：《药学实践杂志》2010年第3期215-216,240,共3页Journal of Pharmaceutical Practice

摘　　要：目的研究中等取代度的羟丙基-β-环糊精合成工艺及其对难溶性药物地塞米松的包埋性能。方法合成了中等取代度的羟丙基-β-环糊精,并按照药典相关规定对产品质量进行了检测。用该产品包合难溶性药物地塞米松,并用相溶解度法对包合物进行了研究。结果合成了取代度为7.875的羟丙基-β-环糊精,产品与地塞米松形成了1:1的包合物,提高地塞米松的溶解度约33倍。结论合成的羟丙基-β-环糊精符合药典要求;通过羟丙基-β-环糊精的包合,提高了地塞米松的水溶性。Objective To investigate synthesis of medium substituted degree hydroxypropyl-β-cyclodextrins and the complex forming capability of dexamethasone.Methods Medium substituted degree hydroxypropyl-β-cyclodextrins were prepared and tested by pharmacopoeia.Dexamethasone were included with the product and performed by the phase-solubility diagram.Results The substituted degree of hydroxypropyl-β-cyclodextrins were 7.875.Dexamethasone was formed a 11 molar ratio inclusion complex with the product and improved solubility about 33 times.Conclusion The product accord with the request of pharmacopoeia.The dissolution capability of dexamethasone was increased by hydroxypropyl-β-cyclodextrins.

关 键 词：羟丙基-Β-环糊精 取代度 包埋 地塞米松 

分 类 号：R943[医药卫生—药剂学]