噻二唑类衍生物的合成与耐缺氧活性  

Synthesis and anoxia endurance activity of thiadiazole derivatives

作　　者：朱占洲[1] 高翔[1] 朱海[2] 赵俊[1] 朱驹[1] 吕加国[1] 周有骏[1] 

机构地区：[1]第二军医大学药学院药物化学教研室,上海200433 [2]第二军医大学药物评价中心,上海200433

出　　处：《药学实践杂志》2010年第3期220-222,共3页Journal of Pharmaceutical Practice

基　　金：第二军医大学大学生创新能力培养基金重点项目(ZD2008035)

摘　　要：目的设计并合成一类新型的噻二唑类衍生物,评价其耐缺氧活性。方法以氨基硫脲为起始原料,经过三步反应合成目标化合物;采用缺氧耐受实验测定目标化合物的耐缺氧活性。结果与结论合成了7个新型的噻二唑类衍生物,其耐缺氧活性经过评价,其中1个化合物的耐缺氧活性突出,具有进一步研究的前景。Objective To design and synthesize novel thiadiazole derivatives and evaluate their anoxia endurance activity.Methods Beginning with thiosemicarbazide,title compounds were synthesized in three steps,then the anoxia endurance activity was evaluated.Results and Conclusion Seven novel thiadiazole derivatives were synthesized and their anoxia endurance activity was evaluated.One of the title compounds exhibited the same anoxia endurance activity as that of acetazolamide,which can be used as the lead for further study.

关 键 词：噻二唑类衍生物 合成 耐缺氧活性 

分 类 号：TQ460.31[化学工程—制药化工]