淀粉微球对乳酸环丙沙星的载药特性和吸附机理研究  

Studies on the drug-loading Property and adsorption mechanism of starch microsphere for ciprofloxacin

作　　者：聂松柳[1] 裘兰兰[2] 马小涛[2] 王柏[3] 何华[2,4] 

机构地区：[1]安徽省六安市人民医院药剂科,六安237005 [2]中国药科大学分析化学教研室,南京210009 [3]中国药科大学药剂教研室,南京210009 [4]药物质量与安全预警教育部重点实验室,南京210009

出　　处：《海峡药学》2010年第5期32-35,共4页Strait Pharmaceutical Journal

摘　　要：目的研究淀粉微球对乳酸环丙沙星的载药性能和吸附机理。方法采用反相乳液聚合法制备空白淀粉微球,以乳酸环丙沙星作为模型药物,吸附载药法考察淀粉微球的载药性能,紫外可见分光光度法测定其载药量及包封率,并考察吸附时间、投药量对载药量的影响,同时对淀粉微球的吸附机理进行了探索,测定了热力学参数。结果反相乳液聚合法制备的空白淀粉微球对乳酸环丙沙星的载药量大于100mg.g-1,包封率可达60%,吸附等温式符合Freundlich公式,可描述为Q=20.36Ce1.73,吸附过程中焓变等于-18.82 kJ.moL-1,熵变等于-22.65J/mol.K-1,结论淀粉微球可作为乳酸环丙沙星的载体,对乳酸环丙沙星的吸附机理以物理吸附为主。OBJECTIVE Studies on the Drug-loading Property and Adsorption Mechanism of Starch Microsphere for ciprofloxacin.METHODS The starch-based microsphere that was crosslinked with epichlorohydrion using a water-in-oil emulsification was prepared.The ciprofloxacin-loaded starch microsphere was made by adsorption method.The drug-loading rate and embedding capacity are mesured by UV spectrum,then the effect of drug quantity,adsorption time,temperature on the drug-loading rate and the adsorption mechanism were investigated.The thermodynamic parameters of starch microsphere adsorpting ciprofloxacin was determined.RESULTS The results show adsorption quantity is more than 100mg·g^-1 while entrapment rate is above 60%,the adsorption isotherm can be described as Q=20.36Ce1.73,the enthalpy change is-18.82 kJ·mol^-1,the entropy change is-22.65 J/mol·K^-1.CONCLUSION The Starch Microsphere can be used as carrier of ciprofloxacin,the main adsorption methanism for ciprofloxacin is the physical adsorption.

关 键 词：淀粉微球 乳酸环丙沙星 吸附载药法 紫外分光光度法 吸附机理 

分 类 号：TQ460.4[化学工程—制药化工]