急性支气管肺炎患儿血清SOD及相关细胞因子测定的意义  

Clinical Significance of Determination of Serum Levels of SOD and Several Relevant Cytokines in Pediatric Patients with Acute Bronchoalveolitis

作　　者：吕卫华[1] 黄卫良[1] 

机构地区：[1]扬州大学第五临床医学院常熟二院儿科,215500

出　　处：《放射免疫学杂志》2010年第3期250-253,共4页Journal of Radioimmanology

摘　　要：目的:探讨六项血清标志物水平的变化与患儿支气管肺炎发生、发展的关系。方法:六项血清标志物测定均采用放射免疫分析。结果:患儿治疗前血清IGF-β及TNF-α水平均较对照组升高显著(P均<0.01);SOD水平则显著低于对照组(P<0.01)。经治疗病情缓解后IGF-β和TNF-α水平均显著降低,后者与对照组比较差异无显著性(P>0.05),前者与对照组比较仍有显著性差异(P<0.05)。SOD水平则已明显升高恢复,与对照组比较无统计学差异(P>0.05)。白介素测定结果显示,患者治疗前IL-10含量显著低于对照组(P<0.01),IL-6及IL-8水平较对照组升高均非常显著(P均<0.01);经治疗IL-6及IL-8水平较对照组均显著下降,但与对照组比较仍有显著差异(P均<0.05);IL-10水平则显著升高,也存在显著性差异(P<0.05)。结论:本文六项指标的测定,对于了解支气管肺炎的病理机制及病情评估有临床意义。Objective To study the clinical significance of determination of serum levels of SOD and several related cytokines in pediatric patients with acute bronchoalveolitis.Methods Serum levels of SOD,IGF-β,TNF-α,IL-6,IL-8 and IL-10 were determined with RIA in 35 pediatric patients both before and after treatment as well as in 35 controls.Results Before treatment the serum levels of SOD and IL-10 in the patients were significantly lower than those in controls（P0.01）,while the serum levels of IGF-β,TNF-α,IL-6 and IL-8 were significantly higher（P0.01）.After one month of treatment,the levels of SOD and IL-10 increased markedly,the levels of SOD being not significantly different from those in controls but the levels of IL-10 were still significantly lower（P0.05）.The serum levels of TNF-α,IGF-β,IL-6 and IL-8 all decresed very much after treatment,however,only TNF-α levels became not significantly different from those in controls while the IGF-β,IL-6 and IL-8 levels remained significantly higher than those in controls（P0.05）.Conclusion The changes of serum levels of SOD,IGF-β,TNF-α,IL-6,IL-8 and IL-10 after treatment were consistent well with the resolution of inflammatory conditions in pediatric patients with acute bronchoalveolitis.

关 键 词：急性支气管肺炎 超氧化物歧化酶 胰岛素样生长因子-β 肿瘤坏死因子-α 白细胞介素-6 8 10 

分 类 号：R135.2[医药卫生—劳动卫生]