天然药物白藜芦醇的产业化合成研究  

Research on the Industrial Systhesis of Nature Medicine(E)-Resveratrol

作　　者：郑兴良[1] 欧阳玲玲[1] 蒋宁飞[1] 

机构地区：[1]长沙理工大学化学与生物工程学院,湖南长沙410114

出　　处：《广州化工》2010年第6期121-122,共2页GuangZhou Chemical Industry

基　　金：白藜芦醇合成新技术(湖南省科学技术厅科技攻关项目2009CK3070)

摘　　要：以3,5-二羟基苯甲酸为起始原料,经甲基化、还原、溴代、Arbuzov重排、Wittig-Horner反应,脱保护基六步反应,成功合成了单一反式结构的(E)-白藜芦醇,反应中间体以及目标化合物用IR、MS1、HNMR进行了结构表征,本合成路线反应步骤少,原料廉价易得,反应条件温和,收率较高,适合大规模的产业化合成。3,5-dihydroxy benzoic acid used as the starting material,via six synthetic steps,in which including methylation,reduction,bromide,Arbuzov rearrangement,Wittig-Horner reaction and then deprotection and the trans isomer（E）-resveratrol was obtained successfully.The reaction intermediates and target compounds using IR,MS,and 1HNMR were characterized,with less reaction steps of this synthetic route,and raw cheaper materials.The reaction condition was mild,and was more suitable for large-scale industrial synthesis,with higher yeild.

关 键 词：白藜芦醇 合成 脱保护 

分 类 号：TQ463.4[化学工程—制药化工]