BMI、WHR与中年糖耐量减低者血管内皮功能相关性研究  

Relationship between BMI,WHR and brachial arterial vasodilation function of middle-aged patients with impaired glucose tolerance

作　　者：刘一平[1] 李建卫[2] 林维强[3] 韦立群[4] 游祖生[5] 

机构地区：[1]福建师范大学体育科学学院,福建福州350007 [2]福建省立医院超声科,福建福州350005 [3]厦门大学医院,福建厦门361005 [4]福建医科大学核医学室,福建福州350004 [5]福建省南平市疾病预防控制中心,福建南平353000

出　　处：《武汉体育学院学报》2010年第6期38-42,共5页Journal of Wuhan Sports University

基　　金：福建省自然科学基金资助项目(X0850028/2008J0272)

摘　　要：探讨体重指数(BMI)、腰臀比(WHR)与中年糖耐量减低(IGT)者血管内皮功能的关系。行标准75g口服葡萄糖耐量试验(75gOGTT),诊断为IGT者101例,年龄在45-59岁。对研究对象检测BMI、WHR、肱动脉血流介导的内皮依赖性血管舒张功能(以△Dia-P%表示)、硝酸甘油介导的非内皮依赖性血管舒张功能(以△Dia-N%表示)、C-型利钠肽(CNP)、内皮素-1(ET-1)、OGTT2h血糖、空腹血糖及胰岛素,计算胰岛素抵抗指数(HOMA-IR),并进行统计学分析。BMI、WHR与空腹血糖、OG-TT2h血糖、空腹胰岛素、HOMA-IR、ET-1、CNP、△Dia-P%具有相关性,而且BMI与△Dia-N%具有相关性。BMI正常、超重与肥胖三组比较,正常组与肥胖组之间ET-1、CNP、△Dia-P%、△Dia-N%、空腹血糖、OGTT2h血糖、空腹胰岛素和HOMA-IR均具有显著性差异,而超重组与肥胖组之间ET-1、空腹血糖、OGTT2h血糖、空腹胰岛素、HOMA-IR具有显著性差异。WHR正常与异常二组比较,空腹血糖、OGTT2h血糖、空腹胰岛素、HOMA-IR、ET-1、CNP、△Dia-P%具有显著性差异。中年IGT者血管内皮功能、糖代谢及胰岛素敏感性受体脂含量、体脂分布的影响,BMI、WHR与血管内皮功能障碍、胰岛素抵抗、糖代谢异常之间存在相关性,而且二者与胰岛素抵抗、糖代谢异常的相关性较血管内皮功能障碍的相关性大,腹型肥胖是胰岛素抵抗的重要相关因素。The purpose of this study was to discuss the relationship between MI, WHR and vascular endothelium function of middle-aged patients with impaired glucose tolerance. 101 persons diagnose4d as IGT, aged between 45-59 were detected on BMI, WHR, △Dia-P%,△Dia- N%, CNP, ET-1, OGTT2h glucose, fasting blood glucose and insulin after taking 75gOGTT. HOMA-IR tics was analyzed. The was caculated and statisresult showed that BMI and WHR had relationship with BMI, WHR, △Dia-P%, ET--1, OGTT2h glucose, fasting blood glucose, fasting insulin, CNP and HOMA- IR, and BMI had relationship whith △Dia-N%. Compared with those of the overweight group and obesity group, ET-1, CNP, △Dia-PM, △Dia-N%,fasting blood glucose, OGTT2h glucose, fasting insulin and HOMA-IR were different between the normal group and the obesity group. ET-1, fasting blood glucose, OGTT2h glucose, fasting insulin and HOMA-IR were significantly different between overweight group and obesity group. The comparison of fasting blood glucose, OGTT2h glucose, rasing insulin, HOMA-IR, ET-1, CNP and △Dia-P% were different between normal WHR and abnormal WHR. It was concluded that the percentage of body fat and distribution of body fat influenced vascular endothelium function, glucose metabolism and insulin sensitivity of middle-aged patients with impaired glucose tolerance. BMI and WHR were related to vascular endothelium dysfunction, insulin resistance, abnormal glucose metabolism.

关 键 词：BMI WHR 糖耐量减低 血管内皮功能 

分 类 号：G804.2[文化科学—运动人体科学]