急性上呼吸道感染患者外周血C反应蛋白测定的临床诊断价值  

Clinical value of C-reactive protein levels in the peripheral blood of patients with acute upper respiratory tract infection

作　　者：田玮[1] 丁宁[1] 

机构地区：[1]首都医科大学附属北京同仁医院急诊科,北京100730

出　　处：《山西医科大学学报》2010年第6期532-533,共2页Journal of Shanxi Medical University

摘　　要：目的研究外周血C反应蛋白(CRP)在急性上呼吸道感染患者中的诊断意义。方法选择急诊首诊为急性上呼吸道感染的患者247例,对患者外周血白细胞计数(WBC)、中性粒细胞百分比(GB%)、CRP分布情况进行统计分析,研究抗菌药物治疗和预后之间的关系。结果 247例患者中,CRP≤8mg/L195例(正常组),CRP>8mg/L52例(增高组)。在CRP增高组WBC均值高于CRP正常组,两组间差异有统计学意义(P<0.01);CRP增高组血清CRP与GB%和WBC均呈正相关(r分别为0.549,0.431,均P<0.01);在血白细胞计数(WBC)、中性粒细胞百分比(GB%)、CRP均正常的93例患者中,未使用(34例)与使用抗菌药物治疗患者(59例)之间5d内退热情况比较差异无统计学意义(P>0.05)。结论外周血CRP含量的增高有助于临床对上呼吸道细菌感染的早期诊断,应作为常规项目推广,以减少抗菌药物的不合理使用。Objective To explore the clinical significance of the C-reactive protein levels（CRP）in peripheral blood for diagnosing patients with acute upper respiratory tract infection. Methods A total of 247 patients firstly diagnosed as upper respiratory tract from the emergency department were collected.The WBC,GB% and CRP in peripheral blood were detected.The relationship between antibiotics therapy and outcomes was investigated. Results Of 247 cases,CRP level was not more than 8 mg/L in 197 cases,and CRP8 mg/L in 52 cases.The mean WBC in patients with CRP8 mg/L was higher than that in patients with CRP≤8 mg/L（P0.01）.In patients with CRP8 mg/L,serum CRP was positively related with GB% and WBC（r=0.549,0.431,P0.01）.The incidence of pyretolysis in 5 d had no difference between antibiotics treated patients and no antibiotics treated patients （P0.05）. Conclusion The peripheral CRP is valuable in the diagnosis of patients with acute upper respiratory tract infection caused by bacteria.

关 键 词：C反应蛋白 急性上呼吸道感染 抗生素 

分 类 号：R56[医药卫生—呼吸系统]