维甲酸软膏质量控制方法的探讨  

Study on quality control of tretinoin ointment

作　　者：赵晓岗 徐兴亚 汪新娣 

机构地区：[1]江苏省扬州市第三人民医院,扬州225008 [2]江苏省扬州市疾病预防控制中心皮肤病性病防治所,扬州225009 [3]江苏省扬州药品检验所,扬州225006

出　　处：《实用药物与临床》2010年第3期197-198,共2页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨维甲酸软膏质量控制方法。方法用紫外分光光度法对维甲酸软膏进行鉴别、含量测定。结果维甲酸在352nm处有最大吸收,平均回收率为100.21%,RSD为1.5%。结论维甲酸软膏中维甲酸的最大吸收波长应在352nm处,测定方法稳定可控。Objective To study the quality control of tretinoin ointment.Methods The identification and contents of tretinoin ointment were determined by ultravidet spectrophotometry.Results The λmax was 352 nm,The average recovery of chloramphenicol was 100.21%,RSD was 1.5%.Conclusion The λmax in 352nm,and the determination is stable and can be controlled.

关 键 词：维甲酸软膏 紫外分光光度法 鉴别 含量测定 

分 类 号：R927.2[医药卫生—药学]