左旋咪唑对雏鸡新城疫灭活苗的免疫增强作用  

Immune Effects of Levomisole on Chickens Inoculated with Oil Emulsion Inactivated Vaccine of Newcastle Disease

作　　者：贺秀媛[1] 

机构地区：[1]农业部郑州生物药品制品厂

出　　处：《西北农业大学学报》1999年第1期60-63,共4页Journal of Northwest Sci-Tech University of Agriculture and Forestry（Natural Science Edition)

基　　金：农业部郑州生物药品制品厂科研基金

摘　　要：对加入０．５ｇ／Ｌ左旋咪唑的ＮＤ灭活油乳剂苗试验组，和未加左旋咪唑的对照组分别以０．１，０．２和０．４ｍＬ／羽的剂量接种４日龄雏鸡，同时设置Ⅱ系活苗免疫组，于接种后３，６，９，１６，２３ｄ测定各组鸡血清中抗ＮＤＶＨＩ抗体，于免疫后２５ｄ，用ＮＤＶ强毒攻击，观察各组的保护情况。结果表明，无论接种剂量为０．１，０．２或０．４ｍＬ／羽的灭活苗试验组，还是与Ⅱ系活苗同时使用的免疫组，加有左旋咪唑的灭活苗产生的ＨＩ抗体比未加左旋咪唑的灭活苗有显著差异（Ｐ＜０．０１），强毒攻击保护率为１００％．Chickens of 4 days old were inoculated with levomisole oil emulsion inactivated vaccine (Levomisole OEV) and oil emulsion inactivated vaccine of newcastle disease (ND).The inoculation doses of the two vaccines were 0.1,0.2 and 0.4 mL per bird,respectively.At 3,6,9,16 and 23 days after vaccination,serum HI antibody titers against NDV of the chickens in each group were detected by Microhaemagg lntination inhibition test (HI).At 25 days after vaccination,chickens were challenged with virulent NDV and the protection rate of each group was calculated,respectively.The results indicated that HI antibody titers of the groups inoculated with levomisole OEV were significant higher than the groups inoculated with OEV.Chickens inoculated with levomisole OEV and OEV obtained 100% of protection rates.

关 键 词：左旋咪唑 新城疫 灭活油佐剂苗 雏鸡 

分 类 号：S858.315.3[农业科学—临床兽医学] S852.42[农业科学—兽医学]