HPLC法测定盐酸坦洛新缓释片中主药的含量  

Determination of the main drug content in tamsulosin hydrochloride sustained-release tablets by HPLC

作　　者：刘镇锋 蔡怿 张述耀[2] 李文隆 

机构地区：[1]广东省汕头市皮肤性病防治院,515000 [2]汕头大学医学院附属肿瘤医院药剂科,广东省汕头市515041 [3]广东省揭阳市药物检验所,522000

出　　处：《临床合理用药杂志》2010年第12期40-41,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的建立以高效液相色谱法测定盐酸坦洛新缓释片中主药含量的方法。方法以C18为色谱柱,流动相为乙腈-高氯酸溶液(40∶60),检测波长为225nm,流速为1ml/min,柱温为35℃,进样量是10μl。结果盐酸坦洛新在4.062～40.62μg/ml浓度范围内有良好的线性关系(r=0.9999),平均回收率为99.69%,RSD=0.54%。结论本方法简便、准确、专属性强,可用于该制剂的质量控制。Objective To establish a method for the determination of the main drug content in tamsulosin hydrochloride sustained-release tablets.Methods HPLC was performed on a C18 column using acetonitrile-perchloric acid solution（40∶60）as the mobile phase at a flow rate of 1ml/min.The detection wavelength was at 225nm.The column temperature was 35℃ and the sample size was 10μl.Results Tamsulosin hydrochloride had a good linear relationship in the concentration range of 4.062~40.62μg/ml（r=0.9999）,the average recovery was 99.69%,RSD=0.54%.Conclusion The method is simple,accurate,special and can be used for the quality control of tamsulosin hydrochloride sustained-release tablets.

关 键 词：盐酸坦洛新缓释片 高效液相色谱法 含量测定 

分 类 号：R927.2[医药卫生—药学]