血清脂联素与2型糖尿病及其大血管病变的相关性研究  

Correlation between serum adiponectin level and macrovascular complications in type 2 diabetes patients

作　　者：单莉[1] 洪云[1] 

机构地区：[1]山东省淄博市中心医院内分泌科,255036

出　　处：《中国综合临床》2010年第6期605-607,共3页Clinical Medicine of China

摘　　要：目的 测定正常人群与2型糖尿病及其大血管病变患者的血清脂联素水平,探讨脂联素与2型糖尿病及其大血管病变的相关性.方法 正常对照组102例,2型糖尿病组116例、2型糖尿病并大血管病变组123例,比较各组的血清脂联素水平,分析其影响因素.结果 ①型糖尿病组及其大血管病变组的血清脂联素水平[分别为（8.62±2.97）、（6.17±2.55）mg/L]较正常对照组[（10.03±4.41）mg/L]降低,大血管病变组的血清脂联素水平较2型糖尿病组更低,差异均有统计学意义（P均〈0.05）;②相关分析显示,脂联素水平与体重指数、腰臀比、胰岛素抵抗指数、空腹胰岛素、糖化血红蛋白、甘油三酯负相关（r值分别为-0.492、-0.581、-0.813、-0.754、-0.619、-0.387,P均〈0.05）;③多元逐步回归分析显示脂联素与胰岛素抵抗指数、空腹胰岛素、糖化血红蛋白呈负相关（r值分别为-0.828、-0.769、-0.631,P均〈0.01）.结论 2型糖尿病及其大血管病变患者的血清脂联素水平降低,低脂联素血症可能与2型糖尿病及其大血管病变相关,在糖尿病动脉粥样硬化的发生、发展过程中有重要作用.Objective To understand the serum adiponectin levels in normal subjects and type 2 diabetes patients with macrovascular complications, to investigate the correlation between adipnectin and macrovascular complications in type 2 diabetes patients. Methods One hundred and two normal subjects, 116 type 2 diabetes patients and 123 type 2 diabetic patients with macrovascular complications were recruited in the current study. The serum adiponectin levels among three groups were compared, and the factors affecting the serum adiponectin were investigated. Results ①The serum adiponectin level was significantly lower in type 2 diabetic patients （8. 62 ± 2. 97） mg/L than that in normal subjects （10. 03 ± 4.41） mg/L, and was the lowest in type 2 diabetic patients with macrovascular complications（6. 17 ± 2. 55） mg/L（P 〈 0.05）. ②Serum adiponetin level was negatively correlated with BMI,WHR,HOMA-IR,fasting insulin level, HbAlC and TG（r = -0.492, -0. 581, -0. 813, -0. 754, -0.619, -0.387, P〈0.05）. ③In a general multivariate regression, HOMA-IR fasting insulin and HbAlc.were negatively correlated with serum adipnectin level （r = - 0. 828, - 0. 769, - 0. 631, P 〈 0. 01）. Conclusions The serum adiponectin level in type 2 diabetic patients is significantly decreased and even more in type 2 diabetic patients with macrovascular complications. These results suggest that lower serum adiponectin level is related to macrovascular complications in type 2 diabetic patients and maybe plays an important role in atherosclerosis in type 2 diabetic patients.

关 键 词：脂联素 2型糖尿病 大血管病变 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]