三七总皂苷渗透泵控释片的研制  

Preparation of Osmotic Pump Controlled Release Tablets of Panax Notoginoside

作　　者：段洪云[1] 张胜[2] 朱鹏飞[3] 刘玉峰[1] 陈立江[1] 

机构地区：[1]辽宁大学药学院,沈阳110036 [2]辽宁省药物研究院,沈阳110015 [3]首都医科大学中医药学院,北京100069

出　　处：《中国实验方剂学杂志》2010年第6期6-9,13,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：辽宁省教育厅科学技术研究项目(20060357);沈阳市科学技术计划项目(1081248-1-00);辽宁"百千万人才工程"培养经费资助;辽宁大学"211工程"三期建设项目资助

摘　　要：目的:制备三七总皂苷渗透泵控释片。方法:考察各因素对药物释放的影响,采用正交试验优化处方。结果:包衣膜的增重和包衣液中PEG400用量对三七总皂苷渗透泵控释片的体外释药行为有显著影响,得到最佳处方为:衣膜增重5%,PEG400的用量为90%,NaCl的用量为30%。结论:通过处方优化可将三七总皂苷制成释药恒速、较完全的渗透泵控释片。Objective：To prepare osmotic pump controlled release tablets of panax notoginoside.Method：The factor influencing the drug release was investigated by the single factor;orthogonal design was used to get the quantitative relationship among the release.Result：The drug release profile in vitro was influenced by membrane weight and the amount of PEG400.The optimum formulation was：PEG400 90%,NaCl 30%,and the membrane weight 5%（as the percent of the core）.Conclusion：The panax notoginoside osmotic pump tablets are attainable by constant speed delivery.

关 键 词：渗透泵控释片 三七总皂苷 正交设计 体外释放 

分 类 号：R283.6[医药卫生—中药学]