氮酮对跌打活络微乳喷雾剂体外透皮吸收影响的研究  

Effect of Azone on Transdermal Absorption in vitro of Dieda Huoluo Microemulsion Spray

作　　者：王利胜[1] 赖宝林[1] 吴阳[1] 周莉玲[1] 

机构地区：[1]广州中医药大学药剂教研室,广州510006

出　　处：《中国实验方剂学杂志》2010年第6期26-29,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金(30672669)

摘　　要：目的:考察不同浓度的渗透促进剂氮酮对跌打活络微乳喷雾剂中蛇床子素和水杨酸甲酯体外透皮吸收的影响。方法:采用Franz扩散池和离体裸鼠皮肤进行体外透皮实验,HPLC同时测定处方中蛇床子素和水杨酸甲酯的渗透量,并计算透皮速率常数、滞后时间。结果:蛇床子素和水杨酸甲酯的体外透皮吸收均符合零级动力学方程;随着氮酮浓度的增加,蛇床子素和水杨酸甲酯的释放速度有降低趋势。结论:本制剂微乳和挥发油本身具有良好的促渗作用,无需另外加入氮酮。Objective：To study the effect of different dosage azone on transdermal absorption in vitro of osthol and methyl salicylate in Dieda Huoluo Microemulsion Spray.Method：The experiment of percutaneous penetration in vitro was operated with the methods of Franz diffusion cell and hairless mice skin,and the penetration quantity of osthol and methyl salicylate was determined by HPLC,and calculate the trandermal rate and lag time.Result：The releasing permeated amount of osthol and methyl salicylate in vitro followed the zero releasing equation.The results showed that the trandermal rate was slower as increased the dosage of azone.Conclusion：The formulation of microemulsion and volatile oil in preparation contributed to the good transdermal absorption in vitro of osthol and methyl salicylate.It’s not necessary to add azone to the preparation.

关 键 词：跌打活络微乳喷雾剂 氮酮 蛇床子素 水杨酸甲酯 透皮吸收 

分 类 号：R283.6[医药卫生—中药学]