大剂量氨溴索对急性百草枯中毒致肺损伤患者血清TNF-α和IL-6的影响  

Effects of high-dose ambroxol on serum TNF-α and IL-6 of patients with pulmonary injury caused by acute paraquat poisoning

作　　者：高渝峰[1] 史晶[1] 刘青[1] 黄澎[1] 曾润生[1] 

机构地区：[1]广州市第十二人民医院急诊科,510620

出　　处：《新医学》2010年第6期369-371,共3页Journal of New Medicine

摘　　要：目的:探讨大剂量氨溴索对急性百草枯中毒致肺损伤患者血清TNF-α与IL-6的影响。方法:31例急性百草枯中毒致肺损伤患者随机分为治疗组(16例)及对照组(15例)。所有患者均予常规治疗,治疗组在此基础上加用氨溴索20mg/(kg·d)静脉滴注,每12h1次,连续治疗3d。双抗体夹心ELISA法检测患者治疗前及治疗3d后外周血血清TNF-α与IL-6水平,同时行肺损伤评分(LIS)评价损伤程度。结果:治疗后两组患者血清TNF-α、IL-6水平及LIS均比治疗前明显下降(P均<0.01),治疗后治疗组上述指标均比对照组明显改善(P均<0.05)。结论:大剂量氨溴索可抑制TNF-α、IL-6的表达,减轻急性百草枯中毒导致的肺损伤。Objective： To investigate the effects of high-dose ambroxol on serum TNF-α and IL-6 of patients with pulmonary injury caused by acute paraquat poisoning. Methods： Thirty-one patients with pulmonary injury caused by acute paraquat poisoning were randomly divided into treatment group （ n = 16 ） and control group （ n = 15）. Both groups were treated with conventional therapy. Treatment group were given ambroxol 20 mg/ （kg · d） intravenously guttae every 12 h for 3 days. Serum TNF-α and IL-6 were measured by ELISA before and after treatment, and lung injury score （LIS） was also assessed in all subjects. Results： Levels of serum TNF-α and IL-6, and LIS in both groups were significantly lower after treatment （P 〈0. 01 ）. Furthermore, treatment group showed significantly more lower than control group （ P 〈 0.05 ）. Conclusion： High-dose ambroxol can inhibit exrpression of serum TNF-α and IL-6, reduce the degree of pulmonary injury caused by acute paraquat poisoning.

关 键 词：氨溴索 大剂量 百草枯中毒 急性 肺损伤 肿瘤坏死因子-α 白介素-6 

分 类 号：R595.4[医药卫生—内科学]