长梗喉毛花酮类化学成分的研究  

Xanthones of Comastoma pedunlulatum

作　　者：袁怡[1] 崔保松[1] 张瑛[1] 李帅[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所,中草药物质基础与资源利用教育部重点实验室,北京100050

出　　处：《中国中药杂志》2010年第12期1577-1579,共3页China Journal of Chinese Materia Medica

基　　金：国家“重大新药创制”科技专项(2009ZX09311-004)

摘　　要：目的：研究长梗喉毛花醋酸乙酯部位中酮类化学成分。方法：应用多种色谱技术进行分离纯化,根据化合物的理化性质和波谱数据鉴定化合物的结构。结果：从长梗喉毛花全草70%乙醇提取物的醋酸乙酯萃取部位对DL-半乳糖胺所致的肝损伤具有保肝作用的活性部位中分离得到9个酮类化合物,分别鉴定为1,8-二羟基-2,6-二甲氧基酮（1）,8-羟基-1,2,6-三甲氧基酮（2）,1,6,8-三羟基-2-甲氧基酮（3）,1,8-二羟基-3,5-二甲氧基酮（4）,1-羟基-3,5,8-三甲氧基酮（5）,1-羟基-3,7-二甲氧基酮（6）,1,2,6,8-四羟基酮（7）,1,3,7-三羟基-4-甲氧基酮（8）,6,8-二羟基-1,2-二甲氧基酮（9）。结论：化合物6~9为首次从该属植物中分离得到。The xanthones in the ethyl acetate extract of Comastoma pedunlulatum were investigated.The chromatographic and spectroscopic techniques were used to isolate and identify the constituents.Nine xanthones were isolated from the active parts of the ethyl acetate portion of the 70% ethanolic extract of C.Pedunlulatum,which possess the protective activity against hepatocyte damage caused by DL-GalN,and identified as 1,8-dihydroxy-2,6-dimethoxyxanthone（1）,8-hydroxy-1,2,6-trimethoxyxanthone（2）,1,6,8-trihydroxy-2-methoxyxanthone（3）,1,8-dihydroxy-3,5-dimethoxyxanthone（4）,1-hydroxy-3,5,8-trimethoxyxanthone（5）,1-hydroxy-3,7-dimethoxyxanthone（6）,1,2,6,8-tetrahydroxyxanthone（7）,1,3,7-trihydroxy-4-methoxyxanthone（8）,6,8-dihydroxy-1,2-dimethoxyxanthone（9）.Among them,compounds 6-9 were isolated from the genus Comastoma for the fist time.

关 键 词：长梗喉毛花 龙胆科 喉毛花属 化学成分 酮 

分 类 号：R284[医药卫生—中药学]