异氟醚或异氟醚复合拉贝洛尔控制性降压对肺内分流的影响  

Effects of Isoflurane with or without Labetalol on Intrapulmonary Shunting during Induced hypotension

作　　者：贺聿国[1] 曾邦雄[1] 姚尚龙[1] 刘俊杰[1] 

机构地区：[1]同济医科大学附属协和医院麻醉科

出　　处：《同济医科大学学报》1999年第1期60-61,共2页Acta Universitatis Medicinae Tongji

摘　　要：研究了异氟醚或异氟醚复合拉贝洛尔控制性降压对肺内分流的影响。２４例择期颅脑手术患者，随机分成两组：单纯异氟醚降压组和异氟醚复合拉贝洛尔降压组。患者的平均动脉压降低３０％左右，分别于控制性降压前、降压达预定值时、维持降压２０ｍｉｎ时和停止降压２０ｍｉｎ后抽取患者动脉血和混合静脉血进行血气分析，采用标准公式计算肺内分流。结果显示，降压期间两组患者的肺内分流较降压前有所增加，但无统计学意义。由此认为，异氟醚或异氟醚复合拉贝洛尔控制性降压对肺内分流的影响较小。The effects of isoflurane with or without labetalol on intrapulmonary shunting were studied during induced hypotension. Twenty four ASAⅠ-Ⅱ patients who required deliberated hypotension for selective cerebral surgery were randomly divided into two groups( n =12 in each group), groupⅠ(isoflurane alone) and groupⅡ(isoflurane plus labetalol). Mean arterial pressure was reduced by approximately 30 %. Arterial and mixed venous blood gas samples were respectively collected and analyzed at four time points to determine right to left shunt fractions(Qs/Qt): 1)immediate before the start of hypotension ( baseline prehypotension), 2) goal hypotension was obtained,3)20 min after stable goal hpotension and 4) 20 min after the end of hypotension. The results showed that Qs/Qt during induced hypotension in the two groups had a slight increase from baseline prehypotension with the difference not being statistically significant. It was indicated that the effects of isoflurane with or without labetalol on Qs/Qt may be slight during induced hypotension.

关 键 词：控制性降压 肺内分流 异氟醚 拉贝洛尔 全身麻醉 

分 类 号：R972[医药卫生—药品] R614.2[医药卫生—药学]