创伤性脑损伤后脑组织Mg^(2+)含量连续性变化及意义  

ACUTE AND PROLONGED ALTERATIONS IN BRAIN MAGNESIUM FOLLOWING TRAUMATIC BRAIN INJURY IN RATS

作　　者：鲁晓杰[1,2] 刘道坤[1,2] 黄长铭[1,2] 陆岩 

机构地区：[1]江苏省无锡市第二人民医院脑外科 [2]南通医学院附属医院脑外科

出　　处：《南通医学院学报》1999年第1期6-7,共2页ACTA Academiae Medicinae Nantong

摘　　要：目的：了解创伤性脑损伤（ｔｒａｕｍａｔｉｃｂｒａｉｎｉｎｊｕｒｙ，ＴＢＩ）后脑组织Ｍｇ２＋含量的连续性变化并探讨其意义；方法：ＳＤ大鼠２８只随机分为假手术对照组（ｎ＝４）、损伤组（ｎ＝２４）。损伤组伤后１、４、２４、４８、７２、１６８ｈ处死，选用原子吸收分光光度法测定脑组织Ｍｇ２＋含量；结果：颅脑损伤后脑组织中Ｍｇ２＋含量在伤后即迅速下降，在２ｈ时达最低值，然后迅速回升，并超过损伤前水平，在７０ｈ时达到最大值，后缓慢下降，并逐渐接近伤前水平（Ｐ＜０．０１）；结论：（１）大鼠ＴＢＩ后脑组织中镁含量可出现持续约２０ｈ的降低，以损伤后２ｈ降低最显著，证实Ｍｇ２＋在ＴＢＩ继发性脑损害早期起重要作用。（２）ＴＢＩ后Ｍｇ２＋治疗“时机窗口”应控制在２４小时内，尽量超早期应用。Objective:To determine and evaluate the length of time that brain magnesium remains suppressed following traumatic brain injury(TBI).Methods:Twenty-eight SD rats were randomly assigned into one of two experimental groups:sham,TBI.Cerebral contusion was produced by dropping weight.The present study has used atomic absorption spectrophotometry to determine the magnesium.Results:Immediately after the traumatic event,brain magnesium significantly declined to minimum at 2h,then increased to preinjury levels about 168h.Conclusions:The results of this study suggests that total magnesium content decrease in brain tissue around cerebral contusion persists 20 hours after trauma,the minimum of magnesium content appears at 2h postinjury and magnesium plays an important role in secondary injury of TBI. Furthermore,therapies targeted at reestablishing magnesium homeostasis after trauma may require administration in a 24-hour period.

关 键 词：创伤性 脑损伤 镁离子 分光光度法 脑组织 治疗 

分 类 号：R651.15[医药卫生—外科学]