电磁脉冲对大鼠学习记忆的影响  

Effect of double NEMP on the learning and memory ability of rats

作　　者：李静[1] 吴彦卓[1] 郭鹞[1] 郑振兴[2] 

机构地区：[1]第四军医大学军事卫勤统计系放射医学教研室,陕西西安710033 [2]西北核技术研究所

出　　处：《第四军医大学学报》1999年第1期74-75,共2页Journal of the Fourth Military Medical University

摘　　要：目的：研究双次核电磁脉冲（ＮＥＭＰ）照射对大鼠学习记忆能力的影响．方法：先用Ｙ迷宫训练照射组（ｎ＝６）和对照组（ｎ＝６）大鼠，使之形成条件反射，以形成条件反射时每只鼠跑迷宫总次数（ＭＴ）、条件反射形成次数（ＣＴ）、分辨学习成绩（ＲＳ）、条件反射百分比（ＰＣ）等为指标，记录每只大鼠原有学习记忆能力，之后用ＮＥＭＰ模拟器重复两次全身照射照射组大鼠，两组（实验组与对照组）分别于照后２４，４８和７２ｈ测试学习记忆能力．结果：照射组和对照组的ＭＴ和ＰＣ在照后的３个时间点均与照前相比有显著差异（Ｐ＜０．０５），两组对应时间点之间相比未见显著差异（Ｐ＞０．０５），但在照射组照后７２ｈ与照后２４ｈ相比ＭＴ明显减少（Ｐ＜０．０５）；对照组ＣＴ仅在２４ｈ时间点和照前有显著差别（Ｐ＜０．０５），照射组ＣＴ２４ｈ时间点与照射前相比未见显著差异（Ｐ＞０．０５），但４８ｈ和７２ｈ时间点与照前相比有显著差异（Ｐ＜０．０５），各对应时间点之间亦未见显著差异；对照组和照射组ＲＳ在２４，４８，７２ｈ时间点与照射前有显著差别（Ｐ＜０．０５），各对应时间点之间未见显著差异（Ｐ＞０．０５）．结论：重复两次ＮＥＭＰ照射可使大鼠学习记忆力在第１日抑制，?AIM: To investigate the effects of the double un-clear electromagnetic pulse (NEMP ) on the learning andmemory ability of rats. METHODS: Control group (n = 6 )and trealed group (n = 6 ) received the training learning andmemory with a Y maze. Mazing total number (MT ). condition reflexion times (CT ), resolving learning score (RS ) andpercentage of condition reflexion (PC ) were selected as theIndices of the learning and memory ability. The treated groupwere radiated with HEMP simulator twice. then the indices(MT.CT. RS. PC ) after 24 h, 48 h, 72 h were estimated.RESULTS: MT and PC at three time points were significantlydifferent berween the control group and treated group (P <0. 05). but three parallel time points of each groupshowed no difference (P>0. 05). In treated group, MT at 72h was less than at 24 h (P<0. 05). In control group, CT dif-ference could be found only between 24 h and preadiation. Intreated group, CT at 48 h was distinctively different with thatat 72 h (P<0. 05). RS of both groupes at three time pointswere differen with that before radiation (P< 0. 05 ). CONCLUSION: Twice NEMP radiation may influence the nervousactivity. Mammalian learning and memory ability reducedfirstly, then tended to recover at 24h, 48h and 72h after radiation respectively.

关 键 词：核电磁脉冲 学习 辐射效应 记忆 

分 类 号：R827.3[医药卫生—临床医学] R338.64