不同介质中活性炭吸附与缓释烟酸的研究  

ADSORPTION AND CONTROLLED RELEASE OF NICOTINIC ACID BY ACTIVATED CARBONS IN VARIOUS MEDIA

作　　者：洪正源[1] 费斌[1] 朱晓玲[1] 池汝安[1] 郭嘉[1] 

机构地区：[1]武汉工程大学化工与制药学院、绿色化工过程省部共建教育部重点实验室,湖北武汉430073

出　　处：《炭素》2010年第2期27-32,共6页Carbon

基　　金：湖北省高等学校优秀中青年科技创新团队计划（T200909）和湖北省教育厅优秀中青年人才计划项目（Q200615001）

摘　　要：研究了活性炭吸附烟酸并在不同介质（蒸馏水、人工胃液、人工肠液）中对烟酸的释放。人工胃液对烟酸的释放有很强的促进作用，累计释放百分率是三种介质中最高的，达到76．36％，并对其原因进行了初步探讨。数学模拟的结果表明，活性炭在三种介质中释放烟酸过程120min前均符合Higuchi模型，整个释放过程符合药物体外释放一级动力学模型。In this paper, adsorption of nicotinic acid onto activated carbons and their controlled release in various media （distilled water, simulated gastric fluid, or simulated intestinal fluid were studied. Simulated gastric fluid promoted the release of nicotinic acid, resulting in the highest release percentage （76.36%）in three various media. The reason was elucidated primarily. The numerical studies showed that in the begining of 120 min the release process coincided with Higuchi model, while the overall process accorded with first order kinetic model.

关 键 词：活性炭 吸附 烟酸 人工胃液 人工肠液 缓释 

分 类 号：TQ424.1[化学工程]