丝氨酸蛋白酶抑制剂亚家族在免疫调节中的作用  

The roles of SERPINA subfamily in immunomodulation

作　　者：黄薇[1] 吴坤陆[1] 

机构地区：[1]中南大学生物科学与技术学院,长沙410078

出　　处：《生命的化学》2010年第3期417-420,共4页Chemistry of Life

摘　　要：丝氨酸蛋白酶抑制剂(serine proteinase inhibitor,SERPIN)是一类分布广泛的蛋白酶抑制剂超家族,在体内生理及病理过程中起重要的调节作用。细胞外SERPIN主要是SERPINA亚家族,其中SERPINA1在体内可抑制TNF-α介导的细胞死亡、调节脂多糖(lipopolysaccharide,LPS)诱导的促炎症因子及抗炎症因子的表达和释放来调节天然免疫,SERPINA3可抑制组织蛋白酶G、MMP-9等抑制过度免疫损害,SERPINA3N可抑制颗粒酶B使宿主细胞介导的免疫反应失活。本文主要以这三个亚家族成员为代表,探讨A亚家族在免疫调节过程中的作用。Serine proteinase inhibitors（SERPINs） are widely distributed protease inhibitor superfamily,and play important regulatory roles in physiological and pathological processes in the body.Extracellular SERPINs are mainly SERPINA subfamily,among which SERPINA1 can inhibit TNF-α-mediated cell death and regulate natural immunity by modifying the expression and release of LPS（lipopolysaccharide）-induced pro-inflammatory cytokines and anti-inflammatory factors,SERPINA3 can in-hibit the damage caused by the excessive expression of cathepsin G,MMP-9,etc,SERPINA3N can inhibit granzyme B to inactivate the host cell-mediated immune response.In this paper,we mainly discuss the roles of these three members,represen-tatives of the SERPINA family,in immune regulations.

关 键 词：SERPINA 免疫调节 炎症反应 

分 类 号：Q55[生物学—生物化学]