氯沙坦对高血压患者血清一氧化氮、内皮素-1和血管内皮功能的影响  

Effect of losartan on serum NO,ET-1 and vascular endothelial function in hypertensive patients

作　　者：康国强[1] 陈树强[2] 林志鸿[1] 蔺佩鸿[1] 晋学庆[3] 

机构地区：[1]福建医科大学附属第一医院急诊科,福州市350005 [2]福建医科大学附属第一医院超声影像科,福州市350005 [3]福建医科大学附属第一医院心内科,福州市350005

出　　处：《中国心血管病研究》2010年第6期419-421,共3页Chinese Journal of Cardiovascular Research

基　　金：福建省卫生厅青年科研基金（2008-2-26）

摘　　要：目的 探讨氯沙坦对高血压患者血清一氧化氮（NO）、内皮素-1（ET-1）和血管内皮功能的影响.方法 入选108例首诊轻、中度高血压患者,给予氯沙坦50～100 mg,qd,共12周;另人选同期健康体检者为正常对照组（对照组100例）.观察高血压患者治疗前后血流介导的肱动脉内皮依赖性血管舒张功能（FMD）、ET-1和NO的变化.结果 随访12周后,与治疗前比较,高血压患者的血压下降,FMD提高,NO上升,ET-1降低（均P〈0.05）.多元线性逐步回归显示,校正年龄、血压、血脂、血糖等因素后,ET-1和NO是FMD的影响因素（均P〈0.05）.结论 氯沙坦改善高血压患者血管内皮功能可能与减少内皮素分泌,增加一氧化氮水平有关.Objective To explore the effect of losartan on serum nitric oxide （NO）, endothelin-1（ET- 1 ） and vascular endothelial function in hypertensive patients. Methods One hundred and eight hypertensive patients were enrolled and treated with losartan 50-100 mg, qd for 12 weeks. 100 healthy subjects were served as control group. Vascular endothelial function （FMD）, ET-1 and NO were determined before and after treatment in hypertensive patients. Results After 12 weeks treatment, the serum level of ET-1 significantly decreased, FMD and NO significantly increased in hypertensive patients （all P〈0.05）. Multiple linear stepwise regression analysis shown that ET-1 and NO were the impact factors of FMD（all P〈0.05）. Conclusion Losartan improvimg vascular endothelial function might be associated with decreasing ET-1 and increasing NO.

关 键 词：氯沙坦 血管内皮 功能 一氧化氮 内皮素-1 

分 类 号：R544.1[医药卫生—心血管疾病]