有妊娠史女性患者的不规则抗体筛查  

Irregular antibody screening of female patients having pregnancy history

作　　者：杨慧[1] 赵建萍[1] 

机构地区：[1]浙江省丽水市中心医院,浙江丽水323000

出　　处：《中国卫生检验杂志》2010年第6期1450-1451,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:对有妊娠史女性患者进行不规则抗体筛查,以确保临床输血安全,减少溶血性输血反应的发生。方法:选择有妊娠史女性患者1785例、无妊娠史女性患者924例作为对照。采用微柱凝胶法进行不规则抗体筛查与鉴定。结果:有妊娠史组和无妊娠史组的不规则抗体筛查阳性率分别为0.78%和0.11%,两组比较存在显著性差异(χ2=5.04,P<0.05)。有妊娠史组确认特异性抗体13例、非特异性抗体1例;13例特异性抗体为抗D 4例、抗E 6例、抗Ec 1例、抗c 1例、抗M1例。无妊娠史组确认特异性抗体1例为抗E。结论:为确保临床输血的安全有效,对有妊娠史女性患者进行不规则抗体筛查很有必要;同时对有妊娠史的孕妇产前进行不规则抗体筛查,可有效防治新生儿溶血病。Objective：To screen irregular antibody in female patients having pregnancy history,so as to ensure the clinic blood transfusion safety and reduce the occurrence of hemolytic transfusion reaction.Methods：Select 1785 female patients having pregnancy history,924 female patients no pregnancy history as controls.Screen and indentify the irregular antibodies by Mico-Column gel technique.Results：The positive rate of irregular antibodies screening in having pregnancy history group and no pregnancy history group is 0.78% and 0.11%,respectively.There is a significant difference between the two groups（χ^2=5.04,P〈0.05）.Having pregnancy history group confirmed specific antibodies 13 cases and non-specific antibodies 1 case;13 cases of specific antibodies are 4 anti-D,6 anti-E,1 anti-Ec,1 anti-c,1 anti-M.No pregnancy history group confirmed specific antibodies 1 case of anti-E.Conclusion：In order to ensure the safe and effective clinic blood transfusion,screening irregular antibody in female patients having pregnancy history is very necessary;At the same time prenatal screening irregular antibody in pregnant women having pregnancy history can effectively prevent and cure hemolytic disease of the newborn.

关 键 词：妊娠史 不规则抗体筛查 

分 类 号：R446.11[医药卫生—诊断学]