肝病患者凝血三项检测及其临床意义  

The clinical significance of 3 indexes of coagulation test in liver diseases

作　　者：何文军[1] 易四维[1] 黄丽英[1] 徐宁[1] 魏琼[2] 

机构地区：[1]广东省中医院芳村分院检验科,广州510370 [2]广东医学院医学检验系,湛江524023

出　　处：《中国医疗前沿》2010年第10期58-59,共2页China Healthcare Innovation

摘　　要：目的探讨肝病患者凝血三项检测的临床意义。方法采用日本SysmexCA-1500全自动凝血仪检测151例肝病患者和70例健康对照者的血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)和纤维蛋白原(FIB)水平三项凝血指标,并按病情轻重分三组进行对比分析。结果肝病患者凝血三项指标有不同程度的异常,其异常程度为肝癌>肝硬化>慢性肝炎,随着病情的加重,PT、APTT明显延长,而FIB则明显降低,与对照组比较差异有统计学意义(p<0.01)。结论血浆凝血三项指标检测可以客观评价肝病患者的凝血功能状况,并与肝病的严重程度相一致,对肝病的诊断、治疗和预后评估有重要意义。Objective To explore the clinical significance of 3 indexes of coagulation test in liver diseases. Methods Plasma prothrombin time （PT）,activated partial thromboplastin time （APTT）,fibrinogen （FIB） were detected in 151 patients with liver diseases and 70 controls by Japanese Sysmex CA-1500 automatic coagulation instrument. Results The results of patients with liver diseases are abnormal to varying degrees,and hepatic carcinoma is more abnormal than hepatic cirrhosis and chronic hepatitis. As the disease increase,PT,APTT was prolonged,while the FIB was significantly reduced,and compared with the control group,there was significant difference （p〈 0.01）. Conclusion 3 indexes of plasma coagulation test can evaluate the coagulation function of patients with liver diseases,and consistent with the severity of liver diseases. They are very important to the diagnosis,treatment and prognosis of liver diseases.

关 键 词：肝疾病 凝血三项 检测 

分 类 号：R446.11[医药卫生—诊断学] R575[医药卫生—临床医学]