血管紧张素转换酶2基因多态性与苯那普利降压水平的关联性分析  

Correlation of angiotensin-converting enzyme 2 gene polymorphism with antihypertensive effects of benazepril

作　　者：陈卿[1,2] 唐迅[1,2] 余灿清[1,2] 陈大方[1,2] 田君[1,2] 曹洋[1,2] 范雯怡[1,2] 曹卫华[1,2] 詹思延[1,2] 吕筠[1,2] 郭晓霞[1,2] 李立明[1,2] 胡永华[1,2] 

机构地区：[1]北京大学公共卫生学院流行病与卫生统计学系,北京100191 [2]中华人民共和国教育部流行病学重点实验室

出　　处：《北京大学学报（医学版）》2010年第3期293-298,共6页Journal of Peking University:Health Sciences

基　　金："十一五"国家科技支撑计划重点项目[2006BAI01A03-(16)]资助~~

摘　　要：目的:探讨血管紧张素转换酶2(angiotensin-converting enzyme2,ACE2)基因rs2106809多态性与服用苯那普利后血压变化情况的关联,以及rs2106809与血管紧张素Ⅱ的1型受体(angiotensinⅡtype1receptor,AGTR1)和血管紧张素原(angiotensinogen,AGT)基因位点之间的交互作用。方法:在1831名高血压患者服用苯那普利2周的基础上,分析rs2106809与血压变化指标的关联,使用广义多因子降维法(generalized multifactor dimensionality reduc-tion,GMDR)分析rs2106809与AGTR1基因8个位点和AGT基因3个位点的交互作用。结果:rs2106809与女性服药后收缩压和脉压差变化情况相关,与男性脉压差变化情况相关,携带T等位基因者降压幅度较大。在男性收缩压变化情况的分析中发现了多基因参与的交互作用模型。结论:rs2106809可能以独立危险因素或交互作用组分的形式影响苯那普利的降压水平。Objective：To explore the correlation of rs2106809 from angiotensin-converting enzyme 2 gene with antihypertensive effects of benazepril,as well as its interactions with polymorphisms of angiotensinogen（AGT）and angiotensin Ⅱ type 1 receptor（AGTR1）gene.Methods：Correlation between rs2106809 and blood pressure reduction was estimated based on a field trail with 1 831 hypertensive patients using benazepril for 2 weeks.Generalized multifactor dimensionality reduction（GMDR）was used to explore the interactions of rs2106809 and 8 single nucleotide polymorphisms（SNPs）of AGTR1 gene and 3 SNPs of AGT gene.Results：rs2106809 was found to be associated with reduction in systolic blood pressure and pulse pressure in women,as well as pulse pressure reduction in men.T allele carriers pre-sented more blood pressure reduction（1.4,1.3 and 0.9 mmHg/T allele respectively）.Gene-gene interactions involving rs2106809 were found in systolic blood pressure reduction of men,and the response to benazepril of non-sensitive genotypes carriers was 8.2（95% confidence interval：6.6-9.7）mmHg,lower than that of sensitive genotypes carriers.Conclusion：rs2106809 might act as an independent influencing factor or component of gene-gene interaction in blood pressure reducing effects of benazepril.

关 键 词：肽基二肽酶A 血管紧张素转换酶抑制药 遗传药理学 血压 广义多因子降维法 

分 类 号：R544.1[医药卫生—心血管疾病]