高氧液对严重烧伤休克期羊淋巴循环TNF-α、IL-6、IL-8水平的影响  

The effects of hyperoxic fluid treatment on the of lymphatic TNF-α、IL-6、IL-8 levers of burn shock goats

作　　者：冉丽[1] 肖虎[1] 禚莹莹[1] 王德昌[1] 王一兵[1] 霍然[1] 冯永强[1] 李强[1] 

机构地区：[1]山东大学附属省立医院烧伤整形科,山东济南250021

出　　处：《中国美容医学》2010年第6期856-858,共3页Chinese Journal of Aesthetic Medicine

基　　金：山东省自然科学基金(Y2006C127);山东省卫生厅青年基金(2009QZ023);山东省优秀中青年科学家科研奖励基金(BS2009YY043)

摘　　要：目的:研究高氧液对严重烫伤休克期羊淋巴循环TNF-α、IL-6、IL-8水平的影响。方法:将20只成年雌性羊随机分为2组,A高氧液组(10只)和B对照组(10只),2组均造成30%TBSAⅢ度烧伤,分别输入高氧液和平衡盐液,经股前淋巴管插管收集淋巴液,用放射免疫分析法检测伤后6、24、48h淋巴液TNF-α、IL-6、IL-8水平的变化,同时测定血氧饱和度(SaO2)。结果:烧伤休克期A组各时相点淋巴液TNF-α、IL-6、IL-8水平显著低于B组。A组SaO2明显高于B组。结论:高氧液对严重烧伤休克期羊淋巴循环有改善作用,降低淋巴液中TNF-α、IL-6、IL-8的水平。Objective To study the effects of hyperoxic fluid treatment on the of lymphatic tumor necrosis factor（TNF-α）,interleukin-6（IL-6）、interleukin-8（IL-8） levers of burn shock goats.Methods 20 female adult goats were randomly divided into the hyperoxic fluid resuscitation group（group A,n=10）,and the control（group B,n=10）.After both groups were inflicted with 30% TBSA full-thickness skin burns,the concentrations of TNF-α,IL-6,IL-8 in lymph were measured at 6,24,48 hours post burn.Results The levers of TNF-α,IL-6,IL-8 in lymph in group A were decreased than group B.Conclusion In the burn shock stage,the hyperoxic fluid resuscitation could improve the lymph circulation and decrease the levers of TNF-α,IL-6,IL-8 in lymph.

关 键 词：烧伤休克 高氧液 淋巴循环 TNF-α IL-6 IL-8 

分 类 号：R644[医药卫生—外科学]