星形细胞肿瘤CT灌注成像参数与MVD的相关性  

Correlation between MSCT Perfusion Parameters and MVD in Astrocytic Tumor

作　　者：王毅[1] 肖华亮[2] 张靖[1] 李雪[1] 冉启胜[1] 陈金华[1] 张伟国[1] 

机构地区：[1]第三军医大学第三附属医院野战外科研究所放射科,重庆400042 [2]第三军医大学第三附属医院野战外科研究所病理科,重庆400042

出　　处：《肿瘤防治研究》2010年第6期660-663,共4页Cancer Research on Prevention and Treatment

基　　金：重庆市科技攻关课题资助项目(CSTC;2007-AC5014)

摘　　要：目的评价星形细胞肿瘤CTP参数与MVD之间的相关性。方法选择我院神经外科53例脑肿瘤患者,经手术和病理学证实为星形细胞肿瘤者纳入研究对象。CTP采用GE LightSpeed 64层螺旋CT机进行灌注扫描,在AW4.2P后处理工作站对原始数据进行后处理,测定肿瘤最大灌注区和对侧正常脑组织的CBF、CBV、MTT及PS值。手术获取脑肿瘤标本,进行组织病理学分级和MVD测定。结果高、低级别星形细胞肿瘤的CBF、CBV、PS和MVD值均显著高于相对应正常侧脑组织(P<0.01),而MTT值的差异无统计学意义(P>0.05)。AA-GBM组的CBF、CBV、PS及MVD值均显著高于LGA组(P<0.01),而MTT值差异无统计学意义(P>0.05)。星形细胞肿瘤CTP参数CBF、CBV、PS与MVD均有显著线性正相关(r=0.819,0.862,0.776,P<0.01),以CBV值最强,而MTT与MVD无相关性(r=-0.320,P>0.05)。结论 CTP参数CBF、CBV及PS值对星形细胞肿瘤血管生成的评价具有很高的准确性。Objective To evaluate the relationship among CTP parameters and MVD in astrocytic tumor. Methods Fifty-three patients with brain tumors underwent CTP examination, and the astrocytic tumors confirmed by operation and pathology were selected as the object of this study. The main observation contents included the maximum perfusion regional CTP parameters and MVD in tumor areas, and the CTP parameters of normal brain tissue in opposite side. Results CBF, CBV, PS and MVD were significant higher in both high and low grade astrocytic tumors, compared with normal brain tissue in opposite side（P0.01）, while MTT result were not significantly different （P0.05）. The CBF, CBV and PS values were strongly and positively correlated with tumor MVD in astrocytic tumors. Pearson correlations, were as follows： CBF and MVD, r=0.819, P0.01; CBV and MVD, r=0.862, P0.01; PS and MVD, r=0.776, P0.01. Hawever, MTT results were not correlated with MVD （r=-0.320, P0.05）. Conclusion The CBF, CBV and PS values of multi-slice CTP are able to quantitatively and accurately reflect the angiogenesis of astrocytic tumors.

关 键 词：多层螺旋CT 灌注成像 星形细胞肿瘤 微血管密度 

分 类 号：R816.1[医药卫生—放射医学] R739.41[医药卫生—临床医学]