急性脑静脉闭塞CT灌注成像的实验研究  

CT perfusion imaging study of acute experimental cerebral venous occlusion

作　　者：王娟[1] 樊长姝[1] 柯祺[1] 周守国[1] 张家雄[1] 

机构地区：[1]广州中医药大学附属佛山中医院CT室,广东佛山528000

出　　处：《实用医学影像杂志》2010年第3期137-139,142,共4页Journal of Practical Medical Imaging

基　　金：广东省医学科研基金资助项目(B2009238);深圳市科技计划资助项目(200802089)

摘　　要：目的观察脑静脉闭塞模型脑实质损害区CT灌注成像(CTP)变化规律,探讨该模型在该病研究中的价值。方法新西兰大白兔28只,随机分为2组(实验组24只,对照组4只)。一侧颈内静脉注入醋酸纤维素聚合物(CAP)合并双侧颈外静脉结扎术后1、3、6、12、24和48h行CTP检查对各组模型的脑血流动力学改变进行观察。结果实验组21只造模成功,其中3h及12h组各有1只在CTP上无明显异常表现,有19只CTP检查示脑血流灌注异常。术后1～3h,病变区脑血容量(CBV)轻度增加或正常,脑血流量(CBF)轻度降低,平均通过时间(MTT)稍延长;6～12h后病变中心区主要表现为CBV和CBF降低,MTT延长,而病变边缘区CBV增加或正常或轻度降低,CBF降低,MTT缩短;12～24h后病变中心区和边缘区CBV和CBF均明显降低,MTT明显延长。各时段病变中心区和边缘区的CBV%、CBF%、MTT%的差异均有统计学意义(P值均<0.05)。对照组未见上述各种异常表现。结论 CT灌注成像可准确、敏感地反映急性脑静脉闭塞模型的血流动力学改变。Objective To evaluate the expeimental model of acute cerebral venous occlusion with computed tomography perfusion（CTP） and histopathology.Methods Twenty-eight New Zealand white rabbits were randomly divided into 2 groups,including experiment group（n=24） and control group（n=4）.CTP was performed at an interval of 1,3,6,12,24 and 48 h after operation which injected CAP solution into left or right internal jugular vein and by ligation of the bilateral external jugular veins.The hemodynamic changes were observed in each group.Results Twenty-one rabbits in experiment group were operated successfully.The operation of 3 rabbits failed because of misoperation and anesthesia.No abnormal appearance was observed in 2 rabbits on CT perfusion imagings.Cerebral blood volume（CBV） was slightly increased or normal,cerebral blood flow（CBF） was slightly decreased and mean transit time（MTT） was slightly prolonged in the lesions after 1-3 h.Both CBV and CBF were decreased in the center of the lesions,while CBV was increased,normal or decreased,CBF decreased in the marginal zone after 6-12 h.CBV and CBF were obviously decreased both in the center and marginal zone after 12-24 h.There was obvious difference among CBV%,CBF% and MTT% in the center and marginal zone of the lesions at each time interval（P 0.05）.No abnormal changes were observed in control group.Conclusion CT perfusion imaging is accurate and sensitive for evaluating the hemodynamics of acute cerebral venous occlusion.

关 键 词：脑静脉闭塞 实验模型 动物 CT灌注成像 

分 类 号：R816.1[医药卫生—放射医学]