银杏叶提取物对早期糖尿病肾病患者IL-6、TNF-a的影响  

Extract of gingko biloba on IL-6,TNF-a in patients with early diabetic nephropathy

作　　者：毛春谱[1] 李小毅[1] 张红梅[1] 蔡文婷[1] 

机构地区：[1]苏州大学附属无锡市第四人民医院内分泌科,无锡214062

出　　处：《重庆医科大学学报》2010年第6期842-844,共3页Journal of Chongqing Medical University

基　　金：无锡市社会发展指导性计划项目(编号:CSZ00833)

摘　　要：目的:探讨银杏叶提取物(Extract of gingko biloba,EGB)对早期糖尿病肾病(Diabetic nephropathy,DN)患者血清细胞因子的影响。方法:将39例早期DN患者随机分为对照组(19例)和治疗组(20例),对照组为常规西药治疗,治疗组在此基础上加用EGB。6个月后,用酶联免疫吸附法(ELISA)测定两组患者治疗前后血清白细胞介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)表达水平,同时观察尿微量白蛋白排泄率、空腹血糖、血肌酐、尿素氮、血脂等指标的变化。结果:与治疗前比较,两组患者治疗后血清IL-6、TNF-α水平均下降(P<0.05),治疗组较对照组下降更为明显(P<0.01)。经q检验显示,治疗组与对照组治疗后同期比较,下降更为明显(P<0.01)。结论:银杏叶提取物可能通过减低血清IL-6、TNF-α的表达,抑制炎症反应,起到对DN的保护作用。Objective：To investigate the effect of extract of gingko biloba （EGB）on inflammatory cytokines in patients with early diabeti cnephropathy（DN）. Methods：Thirty-nine patients with early DN were randomly assigned into the control group （n=19）treated by irbesartan alone and the treated group （n=20）treated by EGB combined with irbesartan for 6 months. Serum interleukin-6（IL-6）and tumor necrosis factor-α（TNF-α）were determined with ELISA before and after treatment,and urinary albumin excretion rate,fasting blood glucose,serum creatinine,blood urea nitrogen and lipid profiles,were examined as well. Results：The levels of IL-6 and TNF-α were significantly lower in both groups after treatment than those before treatment （P〈0.01）. After treatment,IL-6 and TNF-α levels in the treated group were more noticeably reduced than those in the control group according to q test （P〈0.01）. Conclusion：EGB could retard the development of early DN,through decreasing concentration of serum IL-6 and TNF-α,regulating the production of inflammatory cytokins and inhibiting inflammatory reaction.

关 键 词：银杏叶提取物 糖尿病肾病 白细胞介素-6 肿瘤坏死因子-α 

分 类 号：R587.2[医药卫生—内分泌]