仔猪口服利巴韦林毒性实验研究  

Toxic Effects of Ribavirin on Pigs

作　　者：于宏[1] 孙洪磊[1] 杨凤[1] 李宏民[1] 刘思当[1] 

机构地区：[1]山东农业大学动物科技学院,山东泰安271018

出　　处：《中国农业科学》2010年第13期2806-2812,共7页Scientia Agricultura Sinica

基　　金：山东省自然科学基金项目(31364)

摘　　要：【目的】探讨口服不同剂量利巴韦林对猪的毒性作用。【方法】选用12头(15.2±1.5)kg二元杂交仔猪,随机分为空白对照组,每千克体重利巴韦林10、30、90mg口服试验组。连续10d给药,详细观察各组的临床表现,动态检测血细胞、血清、尿液、骨髓造血功能及肝功各项理化指标的变化,最后放血致死剖检,并取材进行病理组织学检查。【结果】仔猪按10mg·kg-1体重口服利巴韦林虽然有一定的临床表现,但无明显的中毒病变;中、高剂量(30、90mg·kg-1体重)的利巴韦林口服对猪的毒副作用明显,甚至导致急性死亡,利巴韦林对各组织器官表现泛嗜毒性,血液、骨髓、消化道、胰腺、心、肝、肾、脑均表现明显的组织学病变。其中溶血性贫血是猪中毒发病的主要机制,胃肠道卡他性坏死性炎症及胰腺病变是猪急性厌食、食欲废绝、便秘的主要原因所在。【结论】猪口服利巴韦林尤其是中、高剂量会产生明显的毒副作用,甚至会引起中毒死亡,因此,严禁利巴韦林用于猪病的防治。【Objective】 The aim of this study was to investigate the toxic effect of different doses of ribavirin on pigs. 【Method】 Twelve pigs were randomly divided into 4 groups including a control group and three experimental groups in order to investigate the toxic effect of different doses of ribavirin on pigs. Ribavirin was administered once daily for 10 consecutive days at a dose of either 10,30,or 90 mg·kg-1. The toxic effects were observed by ethology,blood,serum,urine,bone marrow and pathologic changes before and after administation. 【Result】 The results of this study in pigs indicated that there was no intoxicated significant toxic change between the experimental groups with a daily administration of ribavirin at a dose of 10 mg·kg-1 and the control group,but daily administration of ribavirin at a doses of 30 to 90 mg·kg-1 induced a dose-related toxic effect. The toxic effect showed that the pantropic toxicity and pathological changes in blood,bone marrow,gastrointestinal tract,pancreas,heart,liver,kidney and brain.Hemolytic anemia was the primary mechanism for the pathogenesis of pig poisoning,the reasons which resulted in the loss of appetite and constipation were catarrhal inflammation and necrotizing inflammation of gastrointestinal tract and pancreatopathy. 【Conclusion】 In summary,high doses of ribavirin can increase the risk of death of pigs,so the use of ribavirin for the treatment of swine diseases is not recommended.

关 键 词：利巴韦林 猪 毒性反应 

分 类 号：S858.28[农业科学—临床兽医学]