3-(N,N-二甲氧基乙基)氨基乙酰苯胺合成工艺优化研究  

Optimization of Synthetic Technique for 3-(N,N-Dimethoxyethyl)amino Acetanilide

作　　者：向海艳[1] 宁静恒[2] 

机构地区：[1]南方医科大学药学院,广东广州510515 [2]长沙理工大学化学与环境工程学院,湖南长沙410076

出　　处：《精细化工中间体》2010年第3期44-46,共3页Fine Chemical Intermediates

基　　金：广东省教育部产学研结合项目(2009B090300216)

摘　　要：优化了用2-氯乙基甲醚和间氨基乙酰苯胺合成3-(N,N-二甲氧基乙基)氨基乙酰苯胺的工艺条件。首次采用N,N-二甲基甲酰胺催化合成原料2-氯乙基甲醚,明显缩短了反应时间并获得较高收率。在3-(N,N-二甲氧基乙基)氨基乙酰苯胺的合成中,使用普通缚酸剂纯碱,采用分批加入原料、补充缚酸剂和分阶段升温的方式,有效控制了原料的水解问题,产品收率达98%。笔者研究成果已应用于工业化生产。The synthetic technique for the title compound was optimized via 2-chloroethyl methyl ether and 3-amino acetanilide.DMF was used as the catalyst for the first time for the synthesis of 2-chloroethyl methyl ether,which showed shorter reaction time and afforded higher yield.In this process the acid-binding agent sodium carbonate and the reagents were added in batches and the temperature was increased in 2 steps,which efficiently prevented the starting material from hydrolysis and gave the product in 98% yield.This technique has been commercialized.

关 键 词：3-(N N-二甲氧基乙基)氨基乙酰苯胺 2-氯乙基甲醚 间氨基乙酰苯胺 

分 类 号：TQ246[化学工程—有机化工]