混苯对珠宝加工业女工外周血细胞DNA的损伤  

EFFECT OF BENZENE,TOLUENE,XYLENE OCCUPATIONAL EXPOSURE ON DNA DAMAGE OF PERIPHERAL BLOOD CELLS IN FEMALE JEWEL PROCESSING WORKERS

作　　者：黄丽静[1] 方少波[1] 陈传德[1] 

机构地区：[1]深圳市罗湖区疾病预防控制中心,深圳518020

出　　处：《现代预防医学》2010年第13期2410-2411,共2页Modern Preventive Medicine

摘　　要：[目的]研究苯系物对深圳市罗湖区珠宝加工业女工外周血细胞DNA的损伤作用。[方法]对珠宝加工业镶石清洗工位混苯浓度进行采样检测,应用单细胞凝胶电泳(SCGE)对46名镶石清洗工位接触混苯女工(接触组)和58名服装厂非接触混苯女工(对照组)外周血淋巴细胞DNA损伤进行检测分析,统计细胞数及损伤细胞数,比较DNA损伤细胞率。[结果]18个镶石清洗工位检测到苯系物的时间加权平均浓度中,苯的浓度均高于国家卫生标准,而甲苯、二甲苯的浓度则在正常值范围内。检测46名接触混苯女工外周血的4600个细胞数中,DNA损伤细胞数319个,DNA损伤率为6.93%,对照组外周血检测到的5800个细胞数中,DNA损伤细胞数184个,DNA损伤率为3.17%。接触组与对照组比较差异有统计学意义(P﹤0.05)。[结论]混苯暴露可引起女工外周血细胞DNA的损伤,以苯对DNA的损伤作用更为明显。[Objective] To study the effect of benzene,toluene,xylene occupational exposure on DNA damage in female jewel processing workers.[Methods] Measured the concentrations of benzene,toluene,xylene in working environment,and DNA damage by single cell gel-electrophoresis.[Results] The TWA of benzene was higher than national standard,the DNA damage rate of observation group（6.93%） was higher than that in control group（3.17%）.[Conclusion] Exposure to benzene,toluene,xylene could induce DNA damage on female workers＇ peripheral blood cells.

关 键 词：苯 甲苯 二甲苯 DNA损伤 单细胞凝胶电泳 

分 类 号：R446.11[医药卫生—诊断学]