259例乙型肝炎相关实验室检测结果分析  

RESULT ANALYSIS OF RELATED LABORATORY CHECKS ON 259 CASES OF HEPATITIS B

作　　者：李花[1] 

机构地区：[1]河南省西华县人民医院检验科,西华466000

出　　处：《现代预防医学》2010年第13期2517-2518,共2页Modern Preventive Medicine

摘　　要：[目的]检测乙型肝炎患者的乙型肝炎病毒血清标志物、前S1抗原及HBV-DNA和ALT、AST的水平,探讨其相关性及对乙肝患者诊断和治疗的临床意义。[方法]测定HBV-M及前S1抗原采用酶联免疫吸附试验法,检测HBV-DNA采用荧光定量聚合酶链反应。[结果]Pre-S1Ag在乙型肝炎e抗原(HBeAg)阳性和阴性患者的检出率差异有统计学意义,Pre-S1Ag阳性和阴性的患者ALT、AST异常率差异有统计学意义。[结论]HBVPreS1-Ag与HBeAg之间具有高度相关性,与HBV-DNA有较好的一致性,与肝功能损害密切相关。[Objective] To detect hepatitis B virus serum makers,pre-S1 antigen and HBV-DNA and ALT,AST levels,to explore the clinical significance of the correlation between the indictors and diagnosis and treatment of hepatitis B patients.[Methods] Determined HBV-M and pre-S1 antigen with enzyme linked immunosorbent assay,and determined HBVDNA using fluorescent quantitation polymerase chain reaction.[Results] There was significantly different in pre-S1 antigen between hepatitis B patients with positive HBeAg and negative HBeAg.And there was significantly different in ALT and AST between hepatitis B patients with positive Pre-S1Ag and negative Pre-S1Ag.[Conclusion] HBV preS1-Ag has high correlation with HBeAg,DNA has fairly good compatibility with HBV,which is related with liver function damage.

关 键 词：前S1抗原 乙型肝炎 HBV-DNA ALT AST 

分 类 号：R512.62[医药卫生—内科学]