1型糖尿病早期肾病患者血清MMP-9、MMP-2水平的检测及其临床意义  

Detection of MMP-9 and MMP-2 in type 1 diabetes with incipient diabetic nephropathy and the clinical significance

作　　者：章惺惺[1] 郑佳音[2] 吴文俊[1] 葛胜洁[1] 郑景晨[1] 

机构地区：[1]温州医学院附属第一医院内分泌科,浙江温州325000 [2]温州医学院附属第一医院检验科,浙江温州3250001

出　　处：《温州医学院学报》2010年第3期259-261,共3页Journal of Wenzhou Medical College

基　　金：温州市科技局科研基金资助项目(Y20070124)

摘　　要：目的:测定1型糖尿病(DM)早期肾病患者血清基质金属蛋白酶9(MMP-9)和血清基质金属蛋白酶2(MMP-2)的水平并分析其临床意义。方法:选取1型DM患者54例,依据24 h尿白蛋白排泄率(UAER)将所选患者分为2组:正常白蛋白尿组(NA组)29例;微量白蛋白尿组(MA组)25例,选择门诊体检者20例为正常对照组(NC组)。用酶联免疫吸附(ELISA)法检测血清MMP-9及MMP-2水平。结果:MA组血清MMP-9水平[(379.00±170.15)ng/mL]明显高于NA组[(228.41±147.21)ng/mL]和NC组[(112.80±78.85)ng/mL](均P<0.01);MA组血清MMP-2水平[(297.84±78.50)ng/mL]明显高于NA组[(215.52±40.69)ng/mL]和NC组[(154.80±31.31)ng/mL](均P<0.01)。结论:在1型DM早期肾病患者中MMP-9及MMP-2水平明显升高,提示MMP-9及MMP-2可能参与了糖尿病肾病(DN)的发生、发展。Objective：To detect the serum levels of matrix metalloproteinase-9（MMP-9）and matrix metalloproteinase-2（MMP-2）in type 1 diabetes with incipient diabetic nephropathy and analyze their clinical significance.Methods：Fifty-four patiens with type 1 diabetes were divided into two groups according to urine albumin excretion rate（UAER）：normoalbuminuria（NA,n=29）group and microalbuminuria（MA,n =25） group.Twenty healthy volunteers were used as control group（NC）.MMP-9 and MMP-2 in serum were measured by ELISA.Results：The level of MMP-9 in MA group[（379.00±170.15）ng/mL] was signifi-cantly higher than that in NA group[（228.41±147.21）ng/mL]（P 0.01） and the control group[（112.80±78.85）ng/mL]（P 0.01）.The level of MMP-2 in MA group [（297.84.00±78.50） ng/mL] was signifi-cantly higher than that in NA group [（215.52±40.69n）g/mL]（P0.01） and the control group[（154.80±31.31）ng/mL]（P 0.01）.Conclusion：Higher Serum MMP-9 and MMP-2 in type 1 diabetes with incipient diabetic nephropathy plays an important role in the development of diabetic nephropathy.

关 键 词：糖尿病 1型 糖尿病肾病 基质金属蛋白酶9 基质金属蛋白酶2 

分 类 号：R587.1[医药卫生—内分泌]