老年髋部骨折与降钙素受体基因多态性的关系  

The relationship between calcitonin receptor gene polymorphism and the aged hip fracture

作　　者：任志宏 刘莹[2] 易小波 蔺福辉 王洪 陈晓东 胡鑫华 

机构地区：[1]深圳平乐骨伤科送院脊柱外科,深圳518010 [2]深圳市福田区疾病预防控制中心传染病科

出　　处：《中国骨质疏松杂志》2010年第6期401-403,共3页Chinese Journal of Osteoporosis

摘　　要：目的研究降钙素受体(CTR)基因多态性与老年髋部骨折患者骨密度(BMD)的关系,探讨原发性骨质疏松症(OP)发病的分子机制。方法选取老年髋部骨折患者105人为病例组,并以年龄、性别作配比因素,选取107例非骨折人群为对照组。采用聚合酶链反应-限制性长度多态性(PCR-RFLP)技术对受试者CTR基因进行多态性分析,比较不同基因型各部位BMD值的差异。结果 212例受试对象中,CTR基因型分别为CC型187例(88.21%),CT型25例(11.79%)。病例组和对照组及不同性别间基因型无显著差异。212例受试者各部位的骨密度与年龄呈负相关,与体质量指数正相关。分析基因型与骨密度的关系显示,CT型除在腰椎侧位(L2～L4)及Ward'三角的骨密度比CC型的骨密度值有显著性升高外,其他部位骨密度值之间的差异无统计学意义。结论 CTR基因多态性尚不能作为老年髋部骨折危险性的遗传标志。Objective To study the relationship between calcitonin receptor （CTR） and the aged hip fracture, explore the pathogenesis ofosleoporosis （OP） at the gene level. Methods 105 aged hip fractures served as the cases, and 107 nonfracture persons served as the controls. The ages and sexes between them were all matched. CTR gene were analyzed by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）. Results 212 subjects were all involved in the result analysis. The distribution of CTR were： CC genotype 187 （88.21%） , CT 25 （ 11.79% ）. There was no significant difference in control group and case group and in different sexes. Age showed significant negative correlation with bone mineral density, and body mass index had significant positive correlation with bone mineral density. Subjects with presence of CT genotype group had higher BMD only at lumbar spine （L2-L4 ） and Ward＇s triangle （Ward＇s） sites than subjects in CC genotype group. The mean BMD was of no significant differenceat the other sites. Conclusion CTR genotype may not be used as genetic marker in predicting the risk of developing osteoporosis.

关 键 词：降钙素受体 基因多态性 髋部骨折 骨密度 

分 类 号：R68[医药卫生—骨科学]