微小RNA及其心血管病理生理学作用  

Role of microRNA in cardiovascular pathophysiology

作　　者：汪南平[1] 郝广华[1] 

机构地区：[1]北京大学心血管研究所,分子心血管学教育部重点实验室,北京100191

出　　处：《西安交通大学学报（医学版）》2010年第4期391-397,共7页Journal of Xi’an Jiaotong University（Medical Sciences）

摘　　要：微小RNA是近年发现的内源性非编码RNA小分子,主要在转录后水平调控基因表达,参与包括发育、肿瘤生成、病毒性疾病、免疫性疾病在内的多种生理及病理生理过程。微小RNA在心血管系统中也具有广泛的生物学作用。本文将就微小RNA在心血管病理生理中的作用作简要介绍。MicroRNAs （miRNAs） are endogenous non-coding RNAs discovered in recent years that post-transcriptionally regulate the gene expression. They are implicated in various biological processes including development,oncogenesis,viral and immunological diseases. Many miRNAs are highly expressed in the cardiovascular system and play an important role in cardiovascular health and diseases. In this paper,we briefly review the recent understanding of miRNAs and their role in cardiovascular pathophysiology.

关 键 词：微小RNA 心脏 血管 

分 类 号：R587.1[医药卫生—内分泌] Q938.1[医药卫生—内科学]