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作 者:牛新武[1] 曹伟[1] 冯捷[1] 马慧群[1] 袁景奕[1]
机构地区:[1]西安交通大学医学院第二附属医院皮肤科,陕西西安710004
出 处:《西安交通大学学报(医学版)》2010年第4期509-511,共3页Journal of Xi’an Jiaotong University(Medical Sciences)
基 金:教育部博士点基金新教师项目(编号:20070698071);陕西省科学技术研究发展计划项目(编号:2008K15-06(14))~~
摘 要:目的探讨依曲替酸治疗寻常型银屑病(psoriatic vulgaris,PV)的作用机制。方法观察依曲替酸对30例PV患者的临床疗效,并用原位杂交技术对患者治疗前后皮损中Th1型细胞因子干扰素-γ(IFN-γ)和Th2型细胞因子(IL-4)mRNA进行检测。结果依曲替酸能改善PV患者病情,有效率76.67%。IFN-γ、IL-4 mRNA主要在真皮表皮交界处的淋巴细胞胞质中表达,IFN-γ mRNA的表达治疗前(45.61±9.96)明显高于正常对照(4.40±1.20,P<0.01),治疗后(16.82±7.20)明显下降(P<0.01)。IL-4 mRNA表达无显著变化。结论依曲替酸治疗PV的作用机制可能与其抑制皮肤中IFN-γ mRNA的表达及调节Th平衡有关。Objective To explore the therapeutic mechanism of acitretin for psoriatic vulgaris (PV). Methods The clinical effects of acitretin on 30 patients with PV were observed,and the IFN-γ mRNA/IL-4 mRNA expression in PV patients' skin lesions before and after the treatment was detected by hybrization in situ method. Results The skin inflammation of PV patients was greatly improved with a total efficiency of 76.67%. The expression of IFN-γ mRNA/IL-4 mRNA was detected principally in the lymphocytes at dermoepidermal junction. Prior to the treatment,the expression of IFN-γ mRNA (4.40±1.20) was significantly higher than that in the healthy controls (4.40±1.20)(P0.01). After the treatment,the expression of IFN-γ mRNA (16.82±7.20) was decreased significantly (P0.01),but that of IL-4 mRNA did not change significantly. Conclusion The therapeutic effects of acitretin may be associated with the inhibition of IFN-γ mRNA expression and regulation of dermal Th balance.
分 类 号:R758.63[医药卫生—皮肤病学与性病学]
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